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ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of ubiquitin-rbx1 crosslinks
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049047 | Pride
Ubiquitin Photocrosslinking Crl2vhl Rbx1 
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of BRD4 ubiquitination sites
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049043 | Pride
Protac Mz1 Ubiquitin Crl2vhl Brd4 
ProteomicsHypoxia stabilizes SETDB1 to maintain genome stability
Von Hippel-Lindau (VHL) is a tumor suppressor that functions as the substrate recognition subunit of the CRL2VHL E3 complex. While substrates of VHL have been identified, its tumor suppressive role remains to be fully understood. For further determination of VHL substrates, we analyzed the physical ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD037104 | Pride
Transposable element Setdb1 Genome instability Vhl Proline hydroxylation Inflammation Innate immune response Hypoxia 
GenomicsChIP-seq of BRD4 of HCT116 cells treated with MZ1 or PDD00017273
Targeted protein degradation is a groundbreaking modality in drug discovery ; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation of the anticancer target BRD4 and related hard-to-degrade targets BRD2...
ORGANISM(S): Homo sapiens 
2024-05-17 | GSE262938 | GEO
TranscriptomicsEffect of PDD00017273 and GSK2606414 on MZ1-induced cell death
Targeted protein degradation is a groundbreaking modality in drug discovery ; however, further improvement of the degradation efficacy is demanded. Here, we identify small molecules that enhance the targeted degradation of the anticancer target BRD4 and related hard-to-degrade targets BRD2/3 induced...
ORGANISM(S): Homo sapiens 
2024-05-17 | GSE243615 | GEO
UnknownNative Mass Spectrometry Analysis of Cullin RING Ubiquitin E3 Ligase Complexes in the Context of Targeted Protein Degradation.
Not available
S-EPMC12803233 | biostudies-literature
UnknownHypoxia stabilizes SETDB1 to maintain genome stability.
Not available
S-EPMC10639076 | biostudies-literature
UnknownMitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein.
Not available
S-EPMC6994496 | biostudies-literature
UnknownQuantitative analyses for effects of neddylation on CRL2VHL substrate ubiquitination and degradation.
Not available
S-EPMC8521307 | biostudies-literature
UnknownIntrinsic signaling pathways modulate targeted protein degradation.
Not available
S-EPMC11220168 | biostudies-literature
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