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ProteomicsRequirement of Rbx1 Cullin-RING ligase E3 and Ube2m neddylation E2 in the maintenance of the fitness of Treg cells
the Ube2m-Rbx1 axis is required for the maintenance of homeostasis and functions of Treg cells; and Rbx1 has Ube2m-independent roles in the fitness of Treg cells, suggesting a layer of complexity in neddylation activation of CRLs.
ORGANISM(S): Mus Musculus 
2021-12-03 | PXD030144 |
TranscriptomicsE2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...
ORGANISM(S): Mus musculus 
2009-03-23 | E-GEOD-14088 | biostudies-arrayexpress
GenomicsTranscriptome data of wt, Rbx1- or Ube2m- deficient Treg cells from mice
Transcriptome data of wt, Rbx1- or Ube2m- deficient Treg cells from mice
PRJNA792577 | ENA
GenomicsSingle-cell sequencing of wt and Rbx1-deficient Treg cells from mice
Single-cell sequencing of wt and Rbx1-deficient Treg cells from mice
PRJNA819178 | ENA
GenomicsMechanism study of RBX1 promoting renal clear cell carcinoma invasion, immune suppression, and sunitinib resistance
Mechanism study of RBX1 promoting renal clear cell carcinoma invasion, immune suppression, and sunitinib resistance
PRJNA1298846 | ENA
ProteomicsStructural basis of PROTAC-induced target ubiquitination mechanism - identification of ubiquitin-rbx1 crosslinks
Proteolysis Targeting Chimeras (PROTACs) hijack the ubiquitin proteasome system to ubiquitinate target proteins, targeting them for degradation by the proteasome. An understudied process that is essential to the PROTAC mechanism of action is ubiquitination of the target protein and ubiquitin (Ub) ch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049047 | Pride
Ubiquitin Photocrosslinking Crl2vhl Rbx1 
TranscriptomicsTranscriptome data of wt, Rbx1- or Ube2m- deficient Treg cells from mice
Cullin-RING Ligases (CRLs), upon activation by neddylation, play the key roles in regulating many biological processes. However, how CRL-neddylation regulates the function of Treg cells remains elusive. Here we show that mice with Treg-specific deletion of Rbx1, a RING component of CRLs required for...
ORGANISM(S): Mus musculus 
2021-12-28 | GSE192664 | GEO
GenomicsTranscriptome data of Foxp3-Cre, Rbx1&Sag-deficient Treg cells from mice
Transcriptome data of Foxp3-Cre, Rbx1&Sag-deficient Treg cells from mice
PRJNA995533 | ENA
TranscriptomicsMechanism study of RBX1 promoting renal clear cell carcinoma invasion, immune suppression, and sunitinib resistance
Clear cell renal cell carcinoma (ccRCC) often exhibits drug resistance, highlight_x0002_ing the need to identify novel therapeutic targets. RING box protein 1 (RBX1), an E3 ubiquitin ligase associated with tumor progression, has an unclear role in ccRCC. This study investigated the clinical signific...
ORGANISM(S): Homo sapiens 
2026-02-28 | GSE304059 | GEO
UnknownELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression.
Not available
S-EPMC7064025 | biostudies-literature
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