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TranscriptomicsTranscriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice.
Extrahepatic cholestasis leads to complex injury and repair processes that result in bile infarct formation, neutrophil infiltration, cholangiocyte and hepatocyte proliferation, extracellular matrix remodeling, and fibrosis. To identify early molecular mechanisms of injury and repair after bile duct...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29776 | biostudies-arrayexpress
ProteomicsPAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis
Plasminogen activator inhibitor-1 (PAI-1) has been previously shown to promote lung fibrosis via a mechanism that requires an intact vitronectin (VTN) binding function. However, in the present study, employing two distinct murine fibrosis models, we show that VTN is not required for PAI-1 to drive l...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-14 | PXD054196 | Pride
Lung fibrosis Pai-1 
TranscriptomicsGlobal Gene Expression Profiling in wildtype and PAI-1 Knockout Murine Heart and Kidney.
Fibrosis is defined as an abnormal matrix remodeling and loss of tissue homeostasis due to excessive synthesis and accumulation of extracellular matrix proteins in tissues. At present, there is no effective therapy for organ fibrosis. Previous studies demonstrated that aged plasminogen activator inh...
ORGANISM(S): Mus musculus 
2014-04-23 | E-GEOD-46320 | biostudies-arrayexpress
TranscriptomicsGastrin, PAI-1 and mucosal growth. Whole organism studies in transgenic mice.
We are studying the role of PAI-1 in hypergastrinemic transgenic mice (PAI-1 knockout, HK-ATPase beta knockout and corresponding control strains). As a model of hypergastrinaemia, HK-ATPase beta knockout mice are preferred instead of giving a high dose of proton pump inhibitors daily. We have succes...
ORGANISM(S): Mus musculus 
2016-02-01 | E-MTAB-3853 | biostudies-arrayexpress
TranscriptomicsSynergy between plasminogen activator inhibitor-1 and Snail in tumoral migration
Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasivity. The Plasminogen Activation system (PAs), including urokinase (uPA), its receptor (uPAR), and its inhibitor (PAI-1), also plays a key role in cancer invasion and metastasis, either t...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10395 | biostudies-arrayexpress
GenomicsRNA sequencing of Panc-1 cells co-cultured with CAF overexpressing PAI-1
RNA sequencing of Panc-1 cells co-cultured with CAF overexpressing PAI-1
PRJNA1166227 | ENA
GenomicsExpression profiling of Sk-Hep1 after PAI-1 silencing (RNAi)
Expression profiling of Sk-Hep1 after PAI-1 silencing (RNAi)
PRJNA633599 | ENA
GenomicsSOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis
SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis
PRJNA751053 | ENA
GenomicsPAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity [RNA-Seq]
PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity [RNA-Seq]
PRJNA832105 | ENA
GenomicsPAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity [ChIP-Seq]
PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity [ChIP-Seq]
PRJNA832106 | ENA
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