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ProteomicsPfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages
The pathogenicity of the malaria parasites results from their ability to invade and remodel red blood cells (RBCs), expressing antigenic variant proteins for immune evasion and survival, and then to egress from the host cell. These sequential processes require concerted actions of a large number of...
ORGANISM(S): Plasmodium falciparum 
2024-01-26 | PXD030308 | Pride
Egress Var Apiap2 P.falciparum Epigenetics Invasion 
UnknownInvestigating mechanisms underlying the development of paralysis symptom in a model of MS.
Not available
S-EPMC11956544 | biostudies-literature
GenomicsThe pangenome analysis of the soil-borne fungal phytopathogen Rhizoctonia solani and development of a comprehensive web resource: RsolaniDB
Rhizoctonia solani Kühn is a soilborne basidiomycetous fungus that causes significant damage to many economically important crops. R. solani isolates are classified into 13 Anastomosis Groups (AGs) with interspecific subgroups having distinctive morphology, pathogenicity and wide host range. However...
ORGANISM(S): Rhizoctonia solani 
2020-10-03 | E-MTAB-9588 | biostudies-arrayexpress
GenomicsEndogenous DAF-16 genome-wide recruitment under low Insulin signaling condition in Caenorhabditis elegans
In order to understand the complexity of gene regulation downstream of IIS, we used anti-DAF-16 antibody, we report the first genome-wide ChIP-sequencing study of endogenous DAF-16 recruitment in daf-2(e1370). We also report the average bin-wise normalized read count of ZFP-1 and DAF-16 on DAF-16 s...
ORGANISM(S): Caenorhabditis elegans 
2016-03-01 | E-GEOD-63865 | biostudies-arrayexpress
UnknownSex-chromosome complement and Activin-A shape the therapeutic potential of TNFR2 activation in a model of MS and CNP.
Not available
S-EPMC12107122 | biostudies-literature
TranscriptomicsPlasmodium yoelii RNA-Seq
Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins. Dr Tony Holder's laboratory (NIMR, London) has been...
ORGANISM(S): Plasmodium yoelii 
2011-04-25 | E-MTAB-636 | biostudies-arrayexpress
Transcriptomics[E-MTAB-636] Plasmodium yoelii RNA-Seq
Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins. Dr Tony Holder's laboratory (NIMR, London) has been...
ORGANISM(S): Plasmodium yoelii 
2011-07-14 | GSE30620 | GEO
ProteomicsGeLC-MS/MS of H37Rv and two clinical isolates of Mycobacterium tuberculosis
Clinical isolates were made available from an extensive longitudinal collection of M. tuberculosis isolates circulating in the Western Cape of South Africa. Clinical isolates SAWC3651 and SAWC3517, belonging to the LAM (lineage 4.3) genotype and IS6110 family 14 and 9, respectively, and M. tubercul...
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2017-06-30 | MSV000081205 | MassIVE
TranscriptomicsRNA sequencing of two protein phosphatases(ppm2 and ppm5) knockouts in Plasmodium berghei to study their role in the parasite's sexual development
To identify protein phosphatases (PP) that are essential during asexual blood stage development in Plasmodium berghei, we attempted systematic deletion of the 30 P. berghei PP genes using double homologous recombination. Of these, we performed strand-specific RNA-sequencing (RNA-Seq) analysis for 2...
ORGANISM(S): Plasmodium berghei 
2014-04-16 | E-MTAB-2215 | biostudies-arrayexpress
GenomicsSF3B1 association with chromatin determines splicing outcomes
Much remains unknown concerning the mechanism by which the splicing machinery pinpoints short exons within intronic sequences and how splicing factors are directed to their pre-mRNA targets. Part of the explanation probably lies in differences in chromatin organization between exons and introns. Pro...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-65644 | biostudies-arrayexpress
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