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ProteomicsPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in AML cells
Background The p21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a lim...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056514 | Pride
Acute myeloid leukaemia Phosphoproteomics Machine learning Kinase inhibitors Pak inhibitors Target therapy Pf-3758309 Proteomics Biomarkers Cancer 
ProteomicsSignaling network diversification during differentiation sensitizes AML cells to PAK and MEK inhibitors
A main requirement for precision medicine is the identification of patients that are more likely to respond to a particular drug. AML is a heterogeneous disease in which molecules associated to kinase signaling are frequently mutated. However, no kinase inhibitor has been approved for the treatment ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-15 | PXD005978 | Pride
Aml Phosphoproteomics Kinase-signalling Kinase-inhibitors 
UnknownArrestin 1 and Cone Arrestin 4 Have Unique Roles in Visual Function in an All-Cone Mouse Retina.
Not available
S-EPMC4669854 | biostudies-literature
ProteomicsLow endothelial cell FAK expression reduces pancreatic ductal adenocarcinoma liver metastasis after gemcitabine treatment
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a high level of liver metastasis. Despite substantial advances, resistance to therapy, including gemcitabine, is still a major obstacle to improved progression free survival. Recent studies have indicated that endothe...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD021542 | Pride
Endothelium Chemotherapy Focal adhesion kinase Tumour models Resistance Gemcitabine Phosphoproteomics Metastasis Pancreatic ductal adenocarcinoma Lc-ms/ms 
UnknownArterial cannulation with ultrasound: clinical trial protocol for a randomised controlled trial comparing handheld ultrasound versus palpation technique for radial artery cannulation.
Not available
S-EPMC9763126 | biostudies-literature
UnknownSuppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment.
Not available
S-EPMC9381116 | biostudies-literature
TranscriptomicsTranscription profiling of mouse brown preadipocytes from wild type and IRS knock-out cell lines
Brown preadipocytes were grown to confluence and synchronized by overnight serum starvation. Four independent RNA samples were analyzed from each IRS KO cell line and three independent clones of WT cells were separately analyzed as controls. Splitting of the samples resulted in a total 28 microarr...
ORGANISM(S): Mus musculus 
2007-04-06 | E-CBIL-26 | biostudies-arrayexpress
ProteomicsAnalysis of phospho-proteome change following MST3/4 depletion
Mammalian STE20-like protein kinases 3 and 4 (MST3/4) have recently emerged as crucial regulators of several key cellular processes such as proliferation, migration, and polarity. However, the downstream target pathways which are regulated by the kinase activity of MST3/4 remain poorly characterised...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006167 | Pride
Mst3  mst4  ccm3  gckiii  fam65a  stripak 
UnknownEarly Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: The Budesonide in Babies (BiB) Randomized Clinical Trial.
Not available
S-EPMC12486137 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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