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ProteomicsProtein kinase signalling at the Leishmania kinetochore captured by XL-BioID
Elucidating protein kinase driven signaling pathways is an important but challenging problem in cell biology. Phosphoproteomics has been used to identify many phosphorylation sites, however the spatial context of these sites within the cell is mostly unknown making it difficult to reconstruct signal...
ORGANISM(S): Leishmania Mexicana (ncbitaxon:5665) 
2021-07-04 | MSV000087750 | MassIVE
ProteomicsPhosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantit...
ORGANISM(S): Plasmodium falciparum 
2017-09-22 | PXD002266 | Pride
Malaria Quantitation Signalling Phosphorylation Parasite Invasion Protein kinase g Tandem mass tags 
TranscriptomicsTranscription profiling of human 3T3 Fibrobalasts grown in the presence of fibronectin to assess MAP kinase signalling pathways
3T3 Fibrobalasts grown in the presence of fibronectin to assess MAP kinase signalling pathways. Experiment Overall Design: this experiment include 2 samples and 2 replicates
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3789 | biostudies-arrayexpress
ProteomicsCommunity detection from empirical kinase networks identifies new members of signalling pathways
We use phosphorylation sites to quantify the enrichment of kinase-kinase relationships in response to diferent kinase inhibitors, from which we construct weighted kinase networks, and assess whether the application of community detection algorithms to such networks can provide new insights on the in...
ORGANISM(S): Homo sapiens (Human) 
2023-06-07 | PXD026039 | Pride
Phosphoproteomics Kinase networks Bioinformatics Communitiy detection 
TranscriptomicsCyclin-dependent protein kinase E;1 (CDKE;1) is an essential component for mitochondrial retrograde signalling in Arabidopsis thaliana
Stresses that target mitochondrial function lead to altered transcriptional responses for 100-1000s of genes genome wide, and are signalled via retrograde signalling pathways within the cell. rao1 mutants contain a mutation in a gene encoding a Cyclin-Dependant Kinase E;1 and cannot induce stress re...
ORGANISM(S): Arabidopsis thaliana 
2013-01-28 | E-GEOD-36011 | biostudies-arrayexpress
TranscriptomicsTranscriptome and proteome analysis of tyrosine kinase treated canine mast cell tumour cells identifies potentially KIT signalling-dependent genes
Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied as a therapeutic agent for this tumour type. However, little is known on the downstream tar...
ORGANISM(S): Canis lupus familiaris 
2012-07-24 | E-GEOD-32657 | biostudies-arrayexpress
TranscriptomicsRAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
RAS signalling through Phosphoinositide 3-kinase (PI3-Kinase) has been shown to have an essential role in tumour initiation and maintenance. RAS also regulates cell motility and tumor invasiveness, but the role of direct RAS binding to PI3-Kinase in this remains uncertain. Here, we provide evidence ...
ORGANISM(S): Mus musculus 
2016-02-12 | E-GEOD-77843 | biostudies-arrayexpress
GenomicsRegulation of oestrogen signalling by the receptor tyrosine kinase cKIT stabilises the Barrett’s Oesophagus pre-malignant state
Regulation of oestrogen signalling by the receptor tyrosine kinase cKIT stabilises the Barrett’s Oesophagus pre-malignant state
PRJNA1498120 | ENA
ProteomicsUbiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood. This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular signalling pathways: primarily by controlling cytoskeletal ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-29 | PXD041786 | Pride
Ap-ms Ephb2 Lc-ms/ms 
UnknownMetabolic protein kinase signalling in neuroblastoma.
Not available
S-EPMC10362370 | biostudies-literature
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