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ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
ProteomicsPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in AML cells
Background The p21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a lim...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056514 | Pride
Acute myeloid leukaemia Phosphoproteomics Machine learning Kinase inhibitors Pak inhibitors Target therapy Pf-3758309 Proteomics Biomarkers Cancer 
UnknownSuppression of RAC1-driven malignant melanoma by group A PAK inhibitors.
Not available
S-EPMC5814328 | biostudies-literature
UnknownInhibition of the RAC/PAK Signaling Axis Enhances the Potency of MAPK Cascade Inhibitors Against Uveal Melanoma.
Not available
S-EPMC12564536 | biostudies-literature
ProteomicsSignaling network diversification during differentiation sensitizes AML cells to PAK and MEK inhibitors
A main requirement for precision medicine is the identification of patients that are more likely to respond to a particular drug. AML is a heterogeneous disease in which molecules associated to kinase signaling are frequently mutated. However, no kinase inhibitor has been approved for the treatment ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-15 | PXD005978 | Pride
Aml Phosphoproteomics Kinase-signalling Kinase-inhibitors 
UnknownPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells.
Not available
S-EPMC11907924 | biostudies-literature
UnknownTargeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity.
Not available
S-EPMC5574944 | biostudies-literature
UnknownPAK and PI3K pathway activation confers resistance to KRASG12C inhibitor sotorasib.
Not available
S-EPMC9814377 | biostudies-literature
UnknownSynergistic effect of PAK and Hippo pathway inhibitor combination in NF2-deficient Schwannoma.
Not available
S-EPMC11290668 | biostudies-literature
UnknownPFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK.
Not available
S-EPMC9600610 | biostudies-literature
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