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ProteomicsProteomic analysis of cerebrospinal fluid of amyotrophic lateral sclerosis patients in the presence of autologous bone marrow derived mesenchymal stem cells
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressive motoneuron degenerative disorder. There are still no drugs capable of slowing disease evolution or improving life quality of ALS patients. Thus, autologous stem cell therapy has emerged as an alternative treatment regime to be in...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD053129 | Pride
Mesenchymal stem cells Cerebrospinal fluid Amyotrophic lateral sclerosis Proteomics 
Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part3
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003820 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part2
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003819 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
ProteomicsProteome-wide modulation of S-nitrosylation in Trypanosoma cruzi trypomastigotes upon interaction with the host extracellular matrix
Trypomastigotes from Trypanosoma cruzi adhere to the extracellular matrix (ECM) in order to invade mammalian host cells. Incubation of trypomastigotes with ECM leads to a decrease of nitric oxide synthase (NOS) activity and associated post-translational modifications (PTMs). Herein, resin-assisted e...
ORGANISM(S): Trypanosoma cruzi 
2020-10-27 | PXD018275 | Pride
Post-translational modifications Nitric oxide synthase Histones S-nitrosylation Proteomic Trypanosoma cruzi 
ProteomicsProteomic analysis identifies ATE1-dependent arginylation dysregulation across meningioma grades
Meningiomas are the most common primary brain tumors, yet the molecular pathways that distinguish grade 1 from grade 2 lesions remain insufficiently understood. Among post-translational modifications, N-terminal arginylation—catalyzed by ATE1—regulates protein stability and cellular stress responses...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD071919 | Pride
Meningiomas Post-translational modifications (ptms) Grade comparison Proteomics Arginylation Ate1 
ProteomicsPrognostic accuracy of MALDI-TOF mass spectrometric analysis of plasma in COVID-19
SARS-CoV-2 infection poses a global health crisis. In parallel with the ongoing world effort to identify therapeutic solutions, there is a critical need for improvement in the prognosis of COVID-19. Here, we report plasma proteome finger print that predict high (hospitalized)and low risk(outpatients...
ORGANISM(S): Homo sapiens (Human) 
2021-06-22 | PXD025138 | Pride
Covid-19 Sars-cov-2 Plasma Mass spectrometry Biomarker Prognosis 
ProteomicsExtracellular matrix proteome remodelling in human glioblastoma and medulloblastoma
Medulloblastomas (MBs) and Glioblastomas (GBMs) are high-incidence central nervous system tumors. Different origin sites and changes in the tissue microenvironment have been associated with onset and progression. Here, we describe differences between the ECM signature of these tumors. We compared th...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD023350 | Pride
Glioblastoma Medulloblastoma Proteomics Extracellular matrix Fibronectin 
ProteomicsPrognostic accuracy of Mass Spectrometric Analysis of Plasma in COVID-19
SARS-CoV-2 infection poses a worldwide public health problem affecting millions of people worldwide. There is a critical need for improvements in the noninvasive prognosis of COVID-19. We hypothesized that matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF MS) analysis combined...
ORGANISM(S): Homo sapiens (Human) 
2021-06-22 | PXD021581 | Pride
Covid-19 Sars-cov-2 Plasma Mass spectrometry Biomarker Prognosis 
ProteomicsSnake Venom Extracellular vesicles (SVEVs) reveal wide molecular and functional proteome diversity
This study aimed at characterizing the snake venom extracellular vesicles (SVEVs).Shotgun proteomics analysis of SVEVs was performed to identify the proteome content of these vesicles. TEM, DLS, biochemical activity and cellular assays were performed to characterize the morphology and functionality ...
ORGANISM(S): Crotalus viridis Crotalus atrox Agkistrodon Crotalus cerberus 
2022-03-07 | PXD009506 | Pride
Snake venom Proteomics Extracellular vesicles 
Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part1
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003816 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
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