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TranscriptomicsRegulation of alternative splicing by the core spliceosomal machinery
Abstract: Alternative splicing (AS) plays a major role in the generation of proteomic diversity and in gene regulation. However, the role of the basal splicing machinery in regulating AS remains poorly understood. Here we show that the core snRNP protein SmB/B’ self-regulates its expression by promo...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-26463 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of alternative splicing in Caenorhabditis elegans
Alternative splicing (AS) plays a crucial role in the diversification of gene function and regulation. Consequently, the systematic identification and characterization of temporally regulated splice variants is of critical importance to understanding animal development. We have used high-throughput ...
ORGANISM(S): Caenorhabditis elegans 
2010-12-14 | E-GEOD-25927 | biostudies-arrayexpress
UnknownFabrication of Antibacterial Poly(ethylene terephthalate)/Graphene Nanocomposite Fibers by In Situ Polymerization for Fruit Preservation
Not available
S-EPMC12348518 | biostudies-literature
TranscriptomicsDeep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
We carried out the first analysis of alternative splicing complexity in human tissues using mRNA-Seq data. New splice junctions were detected in 20% of multiexon genes, many of which are tissue specific. By combining mRNA-Seq and EST-cDNA sequence data, we estimate that transcripts from 95% of multi...
ORGANISM(S): Homo sapiens 
2008-11-19 | E-GEOD-13652 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming [AS microarray]
Alternative splicing (AS) is a key process underlying the expansion of proteomic diversity and the regulation of gene expression. However, the contribution of AS to the control of embryonic stem cell (ESC) pluripotency is not well understood. Here, we identify an evolutionarily conserved ESC-specifi...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-31948 | biostudies-arrayexpress
TranscriptomicsRegulation of alternative splicing by histone modifications
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. Here, we demonstrate a direct role for histone modifications in alternative splicing. We find distinctive histone modification signatures which correlate with splicing ou...
ORGANISM(S): Homo sapiens 
2010-02-10 | E-GEOD-19373 | biostudies-arrayexpress
GenomicsGlobal impact of RNA polymerase II elongation inhibition on alternative splicing regulation (ChIP-Seq)
The rate of RNA polymerase II (pol II) elongation can influence splice site selection in nascent transcripts, yet the extent and physiological relevance of this kinetic coupling between transcription and alternative splicing is not well understood. We performed experiments to perturb pol II elongati...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-25494 | biostudies-arrayexpress
ProteomicsFalcon Probe: A High-Pressure and Robust Sampling Interface for Coupling Lossless Liquid Chromatography Injection with In-Situ Nanoliter-Scale Sample Pretreatment
HeLa protein digest and single 293 cell proteome data analyzed by the Falcon probe-based LC-MS analysis system.
ORGANISM(S): Homo Sapiens 
PXD052544 |
TranscriptomicsThe Nuclear-retained non-coding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate tissue- or cell type-specific AS in a concentration and phosphorylation dependent manner. However, the mechanisms tha...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22963 | biostudies-arrayexpress
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
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