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MetabolomicsExtracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness
The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...
2023-01-17 | MTBLS6661 | MetaboLights
UnknownPan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion.
Not available
S-EPMC6821711 | biostudies-literature
UnknownA pan-cancer gamma delta T cell repertoire.
Not available
S-EPMC11291071 | biostudies-literature
MetabolomicsData processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online

Systems biology is the study of complex living organisms, and as such, analysis on a systems-wide scale involves the collection of information-dense data sets that are representative of an entire phenotype. To uncover dynamic biological mechanisms, bioinformatics tools have become essential to fa...

2017-11-23 | MTBLS572 | MetaboLights
ProteomicsProteomic and functional analysis identifies proteins related to embryonic development in decidua of patients with early recurrent miscarriage
Recurrent miscarriage (RM) is the occurrence of repeated pregnancies that end in miscarriage of the fetus before 20 weeks of gestation. Recurrent miscarriages affect about 1-2% of couples trying to conceive; however, mechanisms leading to this complication are largely unknown. Our previous studies u...
ORGANISM(S): Homo sapiens (Human) 
2021-07-30 | PXD023849 | Pride
Recurrent miscarriage  tmt  decidua  ipa  embryonic development 
UnknownA novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs.
Not available
S-EPMC8767042 | biostudies-literature
ProteomicsPlasma proteome profiling reveals the therapeutic effects of the PPAR pan-agonist chiglitazar on insulin sensitivity, lipid metabolism, and inflammation in type 2 diabetes
Chiglitazar is a novel peroxisome proliferator-activated receptor (PPAR) pan-agonist, which passed phase III clinical trials and was newly approved in China for use as an adjunct to diet and exercise in glycemic control in adult patients with Type 2 Diabetes (T2D). To explore the circulating protein...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039827 | Pride
Human Chiglitazar Dia-ms Diabetes Plasma 
UnknownPrognostic and Immunological Role of Key Genes of Ferroptosis in Pan-Cancer.
Not available
S-EPMC8548644 | biostudies-literature
UnknownRole of SERCA3 in the Prognosis and Immune Function in Pan-Cancer.
Not available
S-EPMC9652089 | biostudies-literature
TranscriptomicsWidespread N6-methyladenosine-dependent RNA Structural Switches Regulate RNA-Protein Interactions
We show that N6-methyladenosine (m6A), the most abundant internal modification in mRNA/lncRNA with still poorly characterized function, alters RNA structure to facilitate the access of RBM for heterogeneous nuclear ribonucleoprotein C (hnRNP C). We term this mechanism m6A-switch. Through combining P...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-56010 | biostudies-arrayexpress
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