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ProteomicsThe Leucegene AML surfaceome atlas: immunotherapeutic target identification in AML
We exploited the extensive genomic diversity of the Leucegene cohort of primary human AML specimens to provide an overview of the human AML surfaceome. Due to high cell number requirements, surface proteomics has been underexploited in AML so far, although surface proteome analysis of AML cell lines...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD043772 | Pride
Acute myeloid leukemia Surfaceome Pan-aml antigens 
ProteomicsUpstream open reading frames regulate proto-oncogene translation and encode HLA-presented immunogenic tumor antigens
Upstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data showed that uORFs can encode for biologically active proteins and human leucocyte antigen (HLA)-presented peptides and suggest their potential role in cancer cell ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025716 | Pride
Cancer Uorf Immunotherapy Immunopeptidomics Hla peptides 
ProteomicsImmune surveillance of acute myeloid leukemia is mediated by HLA-presented antigens on leukemia progenitor cells
Persistent therapy-resistant leukemic progenitor cells (LPC) are a main cause of disease relapse and recurrence in acute myeloid leukemia (AML). Specific LPC-targeting therapies may thus improve treatment outcome of AML patients. We demonstrate that LPCs present human leukocyte antigen (HLA)-restric...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD038691 | Pride
Mass spectrometry Acute myeloid leukemia Immunotherapy Immunopeptidomics Leukemic progenitor cells Hla peptides 
ProteomicsMapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy
Identification of physiologically relevant peptide vaccine targets calls for the direct analysis of the entirety of naturally presented human leukocyte antigen (HLA) ligands, termed the HLA ligandome. In this study, we implemented this direct approach using immunoprecipitation and mass spectrometry ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD015748 | Pride
Acute myeloid leukemia Lc-msms 
GenomicsChromatin immunoprecipitation of Drosophila embryos at 6-8h AEL to identify Beaf-32, CP190, CTCF and SuHw proteins binding
ChIP-seq against Beaf-32, CP190 or CTCF was performed in wild-type embryos collected between 6 and 8h after egg laying. For each protein, ChIP-seq was done in biological duplicates. Matched input controls were also generated.
ORGANISM(S): Drosophila melanogaster 
2023-10-31 | E-MTAB-9157 | biostudies-arrayexpress
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