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ProteomicsSILAC analysis of ptp-3 knockout in C. elegans
A ptp-3 mutant and wildtype C. elegans were SILAC labeled and subjected to whole proteome analysis and phosphotyrosine enrichment.
ORGANISM(S): Caenorhabditis elegans 
2016-12-14 | PXD003233 | Pride
Phosoproteomics C. elegans Silac 
TranscriptomicsArgonaute2 mediates compensatory expansion of the pancreatic M-CM-^_-cell
Pancreatic M-CM-^_-cells adapt to compensate for the increased metabolic demand during insulin resistance. While the microRNA pathway has an essential role in the expansion of M-CM-^_-cell mass, the extent of its contribution is unclear. Here we show that miR-184 is silenced in the pancreatic islets...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-46623 | biostudies-arrayexpress
ProteomicsEndoxifen Downregulates AKT Phosphorylation Through Protein Kinase C Beta 1 in ER+/HER2- Breast Cancer
In phase I/II clinical trials, Z-endoxifen demonstrated substantial oral bioavailability and promising antitumor activity in endocrine-refractory estrogen-receptor positive breast cancer (ER+ BC) and other solid tumors, with plasma concentrations reportedly as high as 5 ï�M. Therefore, we explored t...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035007 | Pride
Breast cancer Endoxifen Mass spectrometry Pkc-beta-1 Akt Apoptosis Phosphoproteome 
TranscriptomicsMitochondrial two-component signaling systems in Candida albicans
Two-component signal transduction pathways are one of the primary means by which microorganisms respond to environmental signals. These signaling cascades originated in prokaryotes and were inherited by eukaryotes via endosymbiotic lateral gene transfer from ancestral cyanobacteria. We report here t...
ORGANISM(S): Candida albicans 
2013-07-02 | E-GEOD-45438 | biostudies-arrayexpress
ProteomicsRatios of SILAC labels in E. Coli
3 raw datasets corresponding to known mixtures of lysine and arginine in E. Coli.
ORGANISM(S): Escherichia coli 
2016-08-16 | PXD003845 | Pride
Silac E. coli 
ProteomicsSex and experience dependent regulation of synaptic protein turnover
Synaptic transmission can be carefully tuned through plasticity mechanisms that regulate synaptic strength, structure, and number. In vivo measurements demonstrate remarkable spine dynamics, with subsets of synapses persisting for months. This correlates with the extreme longevity of certain memorie...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD065808 | Pride
Silam Protein turnover Lc-ms/ms 
ProteomicsGlobal phosphotyrosine survey reveals activation of multiple tyrosine kinase signaling pathways in triple negative breast cancer
About 15-20% of all breast cancers are triple negative breast cancers, which are often highly aggressive. We performed global quantitative phosphotyrosine profiling of a large panel of triple negative breast cancer cell lines using high resolution Fourier transform mass spectrometry. Our study ident...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001222 | Pride
Tyrosine phosphorylation Phosphorylation Proteome Triple negative breast cancer 
ProteomicsIdentification of Candidate Substrates for the Golgi Tul1 E3 Ligase Using Quantitative diGly Proteomics in Yeast
Maintenance of protein homeostasis is essential for cellular survival. Central to this regulation are mechanisms of protein quality control in which misfolded proteins are recognized and degraded by the ubiquitin-proteasome system. One well-studied protein quality control pathway requires ER residen...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-11-12 | PXD000918 | Pride
Protein homeostasis Ubiquitination Silac 
ProteomicsOptimizing single cell proteomics on a trapped ion mobility spectrometry for label-free experiments
Although single cell RNA-seq has had a tremendous impact on biological research, a corresponding technology for unbiased mass spectrometric analysis of single cells has only recently become available. Significant technological breakthroughs including miniaturized sample handling have enabled proteom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-02 | PXD039066 | Pride
Dda-pasef Primary t cells Label-free 
ProteomicsA transcriptomic and proteomic map of primary human cell types
Molecular profiling of human primary cell types is essential for a comprehensive understanding of human biology. Here, we describe the transcriptome and proteome map of 28 primary human cell types. Three major clusters of epithelial, endothelial, and mesenchymal cell types were observed at both the ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD062642 | Pride
Primary cells Post-translational modifications Transcriptomics Lc-ms/ms 
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