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ProteomicsDual inhibition of SHP2 and autophagy suppresses NF1-associated malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of premature death for patients with Neurofibromatosis type 1 and no approved targeted therapies are available. Benign plexiform neurofibromas have been successfully treated with selumetinib, a MEK inhibitor, but after progressi...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-20 | PXD035999 | Pride
Shp099 Therapeutics Patient-derived xenograft Kinase inhibitor Genetically engineered mouse model Hydroxychloroquine Neurofibromatosis type 1 Trametinib Kinome 
ProteomicsDual inhibition of SHP2 and autophagy suppresses NF1-associated malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of premature death for patients with Neurofibromatosis type 1 and no approved targeted therapies are available. Benign plexiform neurofibromas have been successfully treated with selumetinib, a MEK inhibitor, but after progressi...
ORGANISM(S): Homo sapiens (Human) 
2024-11-20 | PXD036000 | Pride
Shp099 Therapeutics Patient-derived xenograft Kinase inhibitor Genetically engineered mouse model Hydroxychloroquine Neurofibromatosis type 1 Trametinib Kinome 
ProteomicsDual inhibition of SHP2 and autophagy suppresses NF1-associated malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNSTs) are the leading cause of premature death for patients with Neurofibromatosis type 1 and no approved targeted therapies are available. Benign plexiform neurofibromas have been successfully treated with selumetinib, a MEK inhibitor, but after progressi...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-20 | PXD035998 | Pride
Shp099 Therapeutics Patient-derived xenograft Kinase inhibitor Genetically engineered mouse model Hydroxychloroquine Neurofibromatosis type 1 Trametinib Kinome 
ProteomicsSelective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by activating a shunt pathway that generates the toxic metabolite 24(S),25-epoxycholesterol
LUM2_708738 - MM0299-probe bound protein; LUM2_708739 - MM0299 competition; LUM2_850369 - Ro-alkyne bound protein; LUM2_850370 - Ro 48-8071 competition
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-11 | MSV000091046 | MassIVE
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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