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TranscriptomicsTranscription profiling of human wild type and deltaTOR-containing hepatocyte-like cells to compare total RNA and polysome-bound RNA populations upon hepatocytic differentiation
Comparison of Total RNA and Polysome-bound RNA populations in deltaTOR containing cells and control cells upon hepatocyitc differentiation.
ORGANISM(S): Homo sapiens 
2007-05-11 | E-MEXP-958 | biostudies-arrayexpress
UnknownHypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration.
Not available
S-EPMC7062856 | biostudies-literature
MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
ProteomicsHypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Substances of Homologous Standardized Transplant Products in Tendon Regenerative Medicine
Human fetal progenitor tenocytes (hFPT) produced in defined cell bank systems have recently been characterized and qualified as potential therapeutic cell sources in tendon regenerative medicine. In view of further optimizing the manufacture of the cell-based active substance, the effects of hypoxic...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028359 | Pride
Proteomics Cell manufacture Hypoxia Standardized transplants Tendon affections Human progenitor tenocytes Regenerative medicine 
ProteomicsAn updated proteomic analysis of Drosophila hemolymph after bacterial infection
Using an in-depth Mass Spectrometry based proteomics approach, we provide a comprehensive characterization of the hemolymphatic proteome of adult flies upon bacterial infection. We detected and quantified changes in abundance of several known immune regulators and effectors, including multiple antim...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-05-07 | PXD058897 | Pride
Serine proteases Hemolymph Mass spectrometry Immunity Mitochondria Drosophila melanogaster Antimicrobial peptides Toll pathway Lc-ms/ms Imd pathway 
ProteomicsProteome adaptations of the organohalide-respiring Desulfitobacterium hafniense to fermentative and various respiratory metabolisms
Desulfitobacterium hafniense was originally isolated for its ability to use organohalogens as terminal electron acceptors in the process of organohalide respiration (OHR). However, in contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly versatile energy metabolism with the capaci...
ORGANISM(S): Desulfitobacterium hafniense DCB-2 
2023-01-18 | PXD030393 | Pride
Desulfitobacterium hafniense strain dcb-2  energy metabolism  organohalide respiration  fermentation  quantitative proteomics  tandem mass tag labelling 
ProteomicsResistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy is relap...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038908 | Pride
Combination therapies Pik3r1 Notch1 Resistance mechanisms T-all 
ProteomicsD-Cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1
Selective targeting of cancer cells is a major challenge for cancer therapy. Many cancer cells overexpress the cystine/glutamate antiporter xCT/CD98, a transport system that imports L-cystine to strengthen antioxidant defenses, thereby promoting tumour survival and progression. We have exploited thi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD063479 | Pride
Iron-sulfur cluster Iron-sulfur protein biogenesis Iron homeostasis. Cancer Amino acid 
ProteomicsAnalysis of the fission yeast meiotic proteome reveals a global switch from anabolic to catabolic processes and extensive post-transcriptional regulation.
Progression through meiosis in Schizosaccharomyces pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts and also requires stage-specific, targetted proteolysis of regulatory proteins. We have used SILAC labelling to exam...
ORGANISM(S): Schizosaccharomyces pombe 
2019-02-15 | PXD010438 | Pride
S. pombe Mass spectrometry Silac Time course Meiosis 
TranscriptomicsGenome-wide analysis of Estrogen Receptor-mediated response to acute Estradiol treatment in liver (expression)
Estrogen-based treatments have numerous extra-reproductive effects. On the one hand, they have protective metabolic actions against abdominal fat accumulation, type 2 diabetes, liver steatosis,… But, on the other hand, the oral route of administration, presumably due to a hepatic impact on liver-d...
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-70329 | biostudies-arrayexpress
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