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TranscriptomicsTranscription profiling of Arabidopsis plants with the chlorophyll removed by combining enhancer trap and RNAi approaches
Chlorophyll was removed from the veins of the C3 plant Arabidopsis by combining enhancer trap and RNAi approaches. Three independent transgenic lines were created. These were each compared to the parent line, J1511, in a microarray experiment.
ORGANISM(S): Arabidopsis thaliana 
2009-12-01 | E-MEXP-1988 | biostudies-arrayexpress
ProteomicsFunctional Requirements for a Samd14-Capping Protein Complex in Stress Erythropoiesis
Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals – involving cooperation between SCF/c-Kit signaling and other signaling inputs – are required for the activation and function of erythroid precursors in anemia. O...
ORGANISM(S): Anemia Mus musculus (Mouse) 
2022-08-09 | PXD030467 | Pride
Samd14  capping protein  c-kit  erythropoietin  stress erythropoiesis 
UnknownImpact of poverty and adversity on perceived family support in adolescence: findings from the UK Millennium Cohort Study.
Not available
S-EPMC11424735 | biostudies-literature
TranscriptomicsTranscriptome profiling of genetically modified P. falciparum parasite strains with distinct drug resistance phenotypes
We compared the transcriptomic profiles between P. falciparum strains displaying mutant or wild-type pfcrt or varying in pfcrt or pfmdr1 expression levels All values were normalized using a background pool constituted of 11 transcriptome data sets that constituted a baseline for gene expression fold...
ORGANISM(S): Plasmodium falciparum 
2015-12-09 | E-GEOD-75807 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers and liver tumors from mice fed high-fat diet and high fructose-glucose solution for 52 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67679 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of livers from mice fed high-fat diet and high fructose-glucose solution for 8 weeks
The lack of a preclinical model of nonalcoholic steatohepatitis (NASH) and hepatocellular cancer (HCC) that recapitulates human disease is a major barrier to therapeutic development. We report a high fat-high sugar diet-induced NASH and HCC in a stable isogenic 129S1/SvImJ crossed with C57Bl/6J mice...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-67678 | biostudies-arrayexpress
ProteomicsHuman hemoglobin protects the parasite cytoskeleton during Plasmodium falciparum gametocyte development
Transmission of Plasmodium falciparum requires the differentiation of asexual parasites into male and female gametocytes, which undergo extensive cytoskeletal remodeling, assembling a non-canonical subpellicular microtubule (SPMT) network. Using single-particle cryo-electron microscopy, we determine...
ORGANISM(S): Plasmodium falciparum 
2026-10-15 | PXD082294 | Pride
Plasmodium Subpellicular microtubule 
ProteomicsAtomic models of the conoid from the human parasite Toxoplasma gondii
Apicomplexan parasites, responsible for toxoplasmosis, cryptosporidiosis, and malaria, invade host cells through a unique gliding motility mechanism powered by actomyosin motors and a dynamic organelle called the conoid. Using cryo-electron microscopy (cryo-EM) we determined structures of four essen...
ORGANISM(S): Toxoplasma gondii 
2025-11-14 | PXD068413 | Pride
Toxoplasma Parasite Human Conoid protein 
ProteomicsEvening Complex associated proteins in Arabidopsis by AP-MS
To determine how clock components are integrated with cellular pathways, affinity purification and mass spectrometry (AP-MS) were used to identify proteins that co-precipitate with the evening complex, which is critical regulator of clock, growth, light and flowering pathways.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-03-15 | PXD002606 | Pride
Arabidopsis Elf4 Elf3 Circadian clock 
TranscriptomicsSingle Cell Multi-Omics of Human Preimplantation Embryos Demonstrates Susceptibility to Excess Glucocorticoid Exposure (small RNA part)
We then utilized parallel single-cell RNA sequencing and bisulfite sequencing to explore the impact of GC exposure on the human embryo. In addition, to further explore the role of epigenetic regulation as a mechanism for the observed transcriptional changes, we examined the effects of GCs on small ...
ORGANISM(S): Homo sapiens 
2022-08-02 | E-MTAB-10098 | biostudies-arrayexpress
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