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Proteomicspyruvate dehydrogenase kinase 4 regulate mitochondrial dynamics
Mitochondrial dynamics provides cells with the flexibility required to adapt and respond to mitochondrial toxins, yet the mechanisms underpinning the regulation of mitochondrial dynamics machinery by these stimuli is poorly understood. Here we show that pyruvate dehydrogenase kinase 4 (PDK4) is requ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD028379 | Pride
Pyruvate dehydrogenase kinase 4 Silac Mitochondrial dynamics Drp1 
ProteomicsEnhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease
Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating factors that drive mitochondrial Ca2+ accumulation in ALD remain elusive. Here, we demonstrate that an aberrant increas...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD039478 | Pride
Ptm Mitochondrial dysfunction Pdk4 Grp75 Lc-ms/ms Alcohol-associated liver disease 
UnknownGlobal age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535839 | biostudies-literature
UnknownBurden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535840 | biostudies-literature
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