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MetabolomicsSARS-CoV-2 ORF7a Drives Mitochondrial Dysfunction via PDK4 Activation and Complex I Inhibition

SARS-CoV-2 reprograms host metabolism to promote viral replication and evade immune responses. While infection is known to impair mitochondrial function and enhance glycolysis, the role of viral accessory proteins in these alterations remains unclear. Here, we investigate the metabolic impact of ...

2026-07-09 | MTBLS13338 | MetaboLights
TranscriptomicsExpression data from PDK4 overexpressing (Ad-PDK4 infected) and control (Ad-control infected) mouse liver
We identified PDK4 as a gene with adaptive transcriptional response to chemical stress. Although PDK4 is an energy resource regulator induced by starvation, expression of other fasting-inducible genes was unaffected, indicating additional physiological role of PDK4 for liver adaptation to the chemic...
ORGANISM(S): Mus musculus 
2010-12-25 | E-GEOD-22534 | biostudies-arrayexpress
GenomicsHistone lactylation enhances m6A-mediated PDK4 stabilization to drive osteogenic differentiation in calcific aortic valve disease [RNAseq-PDK4]
Histone lactylation enhances m6A-mediated PDK4 stabilization to drive osteogenic differentiation in calcific aortic valve disease [RNAseq-PDK4]
PRJNA1363891 | ENA
ProteomicsSTAT3-dependent systems-level analysis reveals PDK4 to be associated with favorable outcome in primary prostate cancer.
Prostate cancer has a broad spectrum of clinical behavior, hence biomarkers are urgently needed for risk stratification. We previously described the protective effect of signal transducer and activator of transcription 3 (STAT3) in a prostate cancer mouse model. We now show the importance of STAT3-r...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-04-22 | PXD014251 | Pride
Tcga Metabolomics Pdk4 Oxphos Ffpe-proteomics Gene co-expression network analysis Stat3 Transcriptomics Prostate cancer Tca 
GenomicsExercise Metabolic Memory Halts Pathological Cardiac Hypertrophy via PDK4
Exercise Metabolic Memory Halts Pathological Cardiac Hypertrophy via PDK4
PRJNA1399932 | ENA
GenomicsEffect of Pdk4 smooth muscle cell-specific knockout on atherosclerosis
Effect of Pdk4 smooth muscle cell-specific knockout on atherosclerosis
PRJNA1218623 | ENA
GenomicsCardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging
Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging
PRJNA879068 | ENA
GenomicsRole of Pdk4 in BAPN-induecd aortic dissection in mouse models
Role of Pdk4 in BAPN-induecd aortic dissection in mouse models
PRJNA1392438 | ENA
TranscriptomicsExpression data from PDK4 overexpressing (Ad-PDK4 infected) and control (Ad-control infected) mouse liver
We identified PDK4 as a gene with adaptive transcriptional response to chemical stress. Although PDK4 is an energy resource regulator induced by starvation, expression of other fasting-inducible genes was unaffected, indicating additional physiological role of PDK4 for liver adaptation to the chemic...
ORGANISM(S): Mus musculus 
2010-12-25 | GSE22534 | GEO
GenomicsGene expression in activated WT or PDK4 -/- CD4+ T cells
Gene expression in activated WT or PDK4 -/- CD4+ T cells
PRJNA679025 | ENA
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