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we developed a novel brain-penetrant inhibitor of G9a, MS1262, across the blood-brain barrier to block this G9a-regulated, proteopathologic mechanism. Intermittent MS1262 treatment of multiple AD mouse models consistently restored both cognitive and noncognitive functions to healthy levels. Comparis...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-18 | PXD047045 | Pride
Nucleophosmin (NPM1) is a nucleolar protein frequently mutated in haematopoietic malignancies and overexpressed in many solid tumours, but little is known about its functional role in carcinogenesis. Here, we identify NPM1 as a commonly upregulated gene following APC loss in tissues that positively ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-12 | PXD062969 | Pride
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