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TranscriptomicsImage based identification and targeting of cancer stem cells in pancreatic adenocarcinoma (PDAC)
Purpose: The goals of this study were to identify quantitative gene expression differences between wild type, Musashi1 null, Msuashi2 null and Musashi1/Musashi2 null MIAPaCa2 pancreatic cancer cells mRNA profiles of MIA PaCa-2 cancer cells were generated by deep sequencing, in triplicate, using Ill...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-75797 | biostudies-arrayexpress
TranscriptomicsHOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis.
In order to determine the role of HOXB7 gene in cell lines derived from pancreatic ductal adenocarcinoma (MIA PaCa-2 e Capan-1), we performed its silencing utilizing the technique of RNA interference (RNAi). Total RNA derived from the inhibition as well as from parental cells was quantified in Bioan...
ORGANISM(S): Homo sapiens 
2013-07-26 | E-GEOD-46393 | biostudies-arrayexpress
ProteomicsAnti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development
Cancers with activating mutations of KRAS show a high prevalence and poor prognosis but remain intractable, requiring innovative strategies to overcome the poor targetability of KRAS. Here, we report that KRAS expression was post-translationally up-regulated through the deubiquitination of KRAS prot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052379 | Pride
Kras protein deubiquitination  ndrg3  usp9x  pancreatic cancer 
UnknownA structured collaborative approach to intervention design using a modified intervention mapping approach: a case study using the Management and Interventions for Asthma (MIA) project for South Asian children.
Not available
S-EPMC7607819 | biostudies-literature
TranscriptomicsDNA sensing and Interferon Beta 1 transactivation drive radiation-induced anti-tumor immune effects in human pancreatic cancer cells
We demonstrate that a clinically relevant X-ray hypofractionation regimen (3x8 Gy) of multiple PDAC cel lines effectively induces immunogenic cell death and transactivates Interferon beta-1 in a STING-dependent manner. RNA-seq analyses showed a global and steady upregulation of type I interferon res...
ORGANISM(S): Homo sapiens 
2024-08-12 | E-MTAB-13096 | biostudies-arrayexpress
UnknownAntarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis.
Not available
S-EPMC7699584 | biostudies-literature
UnknownLow-Molecular-Weight Fish Collagen Peptide (Valine-Glycine-Proline-Hydroxyproline-Glycine-Proline-Alanine-Glycine) Prevents Osteoarthritis Symptoms in Chondrocytes and Monoiodoacetate-Injected Rats.
Not available
S-EPMC10744650 | biostudies-literature
UnknownMaternal immune activation alters brain microRNA expression in mouse offspring.
Not available
S-EPMC6186947 | biostudies-literature
UnknownReconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana.
Not available
S-EPMC9464250 | biostudies-literature
UnknownReversing behavioural abnormalities in mice exposed to maternal inflammation.
Not available
S-EPMC5796433 | biostudies-literature
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