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MetabolomicsShort-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

INTRODUCTION: Bariatric surgery is known to be the most effective treatment for weight loss in obese patients and for the rapid remission of obesity-related comorbidities. These short-term improvements result from not only limited digestion or absorption but also dynamic changes ...

2022-03-17 | MTBLS2472 | MetaboLights
ProteomicsA mitochondrial proteome profile of type 2 diabetes mellitus in skeletal muscles
The goal of the project is to understand the mitochondrial proteome profiles related to T2DM. We performed comprehensive proteome profiling of mitochondria isolated from skeletal muscles in nine T2DM patients and nine control subjects with normal glucose tolerance (NGT).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083560 | MassIVE
ProteomicsPGRC Cancer Proteome Study of Gastric Tissue
The goal of the project is to analyze different layers of proteome information including protein abundance and post-translational modifications of PGRC gastric tissue samples. Three pairs of human gastric cancer and adjacent normal tissues were extensively characterized by serial enrichments of phos...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080818 | MassIVE
ProteomicsPGRC Cancer Proteome Study of Gastric Tissue
The goal of the project is to analyze different layers of proteome information including protein abundance and post-translational modifications of PGRC gastric tissue samples. Three pairs of human gastric cancer and adjacent normal tissues were extensively characterized by serial enrichments of phos...
ORGANISM(S): Homo sapiens (Human) 
2016-03-18 | PXD003115 | Pride
Human Lc-msms Multi-dimenstional proteome analysis Early onset gastric cancer 
ProteomicsA mitochondrial proteome profile of type 2 diabetes mellitus in skeletal muscles
The goal of the project is to understand the mitochondrial proteome profiles related to T2DM. We performed comprehensive proteome profiling of mitochondria isolated from skeletal muscles in nine T2DM patients and nine control subjects with normal glucose tolerance (NGT).
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD004312 | Pride
Human Mitochondrial proteome Type 2 diabetes mellitus (t2dm) Lc-ms/ms 
ProteomicsComprehensive proteome profiling of platelet identified a protein profile predictive of responses to an antiplatelet agent sarpogrelate.
Here, we performed a comprehensive proteome profiling of platelets collected from 18 healthy subjects before and after administration of sarpogrelate. For each subject, platelets were isolated before and then again after drug administration to investigate the alteration in the platelet proteome by s...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD003613 | Pride
Platelet proteomes Antiplatelet agents And drug responses. Lc-ms/ms 
ProteomicsHypoxia increases the methylated histones to prevent histone clipping and redistribution of heterochromatin during Raf-induced senescence.
Hypoxia in stem cell niches and inner core of solid tumors contributes to cellular senescence and differentiation inhibition. It directly increases histone methylationby inhibiting the activities of O2-and α-ketoglutarate (α-KG)-dependent histone lysine demethylases. This study is the first to demon...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD033971 | Pride
Human Top-down Histone Proteomics 
ProteomicsDeepMRM: targeted proteomics data interpretation package with deep learning-based object detection
LC-MRM-MS/MS data of 66 Pancreatic ductal adenocarcinoma patients. Includes peak list files (.mzML), quantification results (.tsv) and raw files (.d) of the three replicate data of all patients.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-19 | MSV000089914 | MassIVE
MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
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