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TranscriptomicsVariation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects
Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly mutated genes encode the chromatin regulators PBRM1, SETD2, and BAP1. How these mutations alter the ch...
ORGANISM(S): Homo sapiens 
2013-10-17 | E-MTAB-1936 | biostudies-arrayexpress
ProteomicsChemoproteomic Cysteine Selectivity of VVD-446 and VVD-860
Global assessment of cysteine selectivity for VVD compounds that covalently engage KEAP1 C151
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071609 | Pride
Vvd-860 Keap1 Vvd-446 
UnknownComplex modeling with detailed temporal predictors does not improve health records-based suicide risk prediction.
Not available
S-EPMC10036475 | biostudies-literature
UnknownParent-focused prevention of adolescent health risk behavior: Study protocol for a multisite cluster-randomized trial implemented in pediatric primary care.
Not available
S-EPMC8802622 | biostudies-literature
UnknownInterferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer.
Not available
S-EPMC6897992 | biostudies-literature
ProteomicsChemoproteomic Cysteine Selectivity of VVD-065, VVD-330 and VVD-325
Global assessment of cysteine selectivity for VVD compounds that covalently engage KEAP1 C151
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071657 | Pride
Nrf2 Keap1 Vvd-330 Vvd-065 Vvd-325 
ProteomicsChemoproteomic Profiling of VVD-065 Selectivity
The NRF2 transcription factor is constitutively active in cancer where it functions to maintain oxidative homeostasis and reprogram cellular metabolism. NRF2-active tumors exhibit NRF2-dependency and resistance to chemo/radiotherapy. Here we characterize VVD-065, a first-in-class NRF2 inhibitor that...
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071555 | Pride
Nrf2 Keap1 Vvd-065 
ProteomicsChemoproteomic analysis of VVD-065 Protein Selectivity
Assessment of VVD-065 protein selectivity via protein enrichment with VVD-369, an alkylated version of VVD-065.
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD071607 | Pride
Vvd-065 Keap1 Vvd-369 
UnknownMassively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation.
Not available
S-EPMC12339365 | biostudies-literature
GenomicsA role for Widely Interspaced Zinc finger (WIZ) in retention of the G9a methyltransferase on chromatin
G9a and GLP lysine methyltransferases form a heterodimeric complex that is responsible for the bulk of cellular mono- and di-methylation on histone H3 lysine 9 (H3K9me1/me2). Widely Interspaced Zinc finger (WIZ) associates with the G9a/GLP protein complex, but its role in lysine methylation is poor...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-67317 | biostudies-arrayexpress
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