Sort   by:  
 Page size 
TranscriptomicsA Pathobiological Role of the Insulin Receptor in CLL.
Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL wi...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-26526 | biostudies-arrayexpress
ProteomicsmiR-181a Restores Mitochondrial Dynamics in Skeletal Muscle Ageing
Global label free analysis of quadricesp skeletal muscle tissue from adult and old mice subjected to 15 min of isometric contractions.
ORGANISM(S): Mus musculus (Mouse) 
2020-04-15 | PXD010091 | Pride
Mitophagy Mir-181a Skeletal muscle 
TranscriptomicsClonal evolution and devolution following chemotherapy in adult acute myelogenous leukemia
The frequent occurrence of persistent or relapsed disease following induction chemotherapy in AML necessitates a better understanding of the clonal relationship of AML in various disease phases. In this study, we employed SNP 6.0 array-based genomic profiling of acquired copy number aberrations (aCN...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-41646 | biostudies-arrayexpress
TranscriptomicsRepertoire of miRNAs in epithelial ovarian cancer determined by next generation sequencing of small RNA cDNA libraries
Background: MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently shown promise as blood-based biomarkers for cancer detection. Epithelial ovarian cancer is a deadly disease for which improved outcomes could be achieved by successful early detectio...
ORGANISM(S): Homo sapiens 
2009-03-12 | E-GEOD-15190 | biostudies-arrayexpress
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 1)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS204 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 2)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS205 | MetaboLights
ProteomicsLFQ of mNeonGreen-Trap IP-MS from cells expressing HKDC1-mNeonGreen
Cells stably expressing full-length HKDC1-mNeonGreen or △N20 HKDC1-mNeonGreen proteins were grown in a 10-cm dish and were treated with or without antimycin/oligomycin for 3h, and then cross-linked with 0.1% formaldehyde for 10min at room temperature. After cross-linking was quenched with 100mM glyc...
ORGANISM(S): Homo Sapiens (human) 
2024-01-21 | PXD040970 | JPOST Repository
TranscriptomicsMicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries
We used massively parallel pyrosequencing to discover and characterize microRNAs (miRNAs) expressed in human embryonic stem cells (hESCs). Sequencing of small RNA cDNA libraries derived from undifferentiated hESC and from isogenic differentiating cultures yielded a total of 425,505 high-quality sequ...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-21722 | biostudies-arrayexpress
TranscriptomicsNF1 inactivation in adult acute myelogenous leukemia
Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML). Conclusions: NF1 null states are present in 7/95=7% of adult AML and delineate a disease subset that could be preferentially targeted by Ras or mTOR-directed therapeut...
ORGANISM(S): Homo sapiens 
2010-12-02 | E-GEOD-21107 | biostudies-arrayexpress
TranscriptomicsComparative genomics of Steinernema reveals deeply conserved regulatory networks in nematodes
Parasitism is a major ecological niche for a variety of nematodes. Multiple nematode lineages have specialized as pathogens, including deadly parasites of insects that are used in biological control. We have sequenced and analyzed the draft genomes and transcriptomes of the entomopathogenic nematode...
ORGANISM(S): Caenorhabditis elegans 
2015-06-05 | E-GEOD-68588 | biostudies-arrayexpress
Sort   by:  
 Page size