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GenomicsCIDR: Genome Wide Association Study in Familial Parkinson Disease (PD)

This proposal brings together the two largest NIH funded genetic studies focused on the identification of novel genes that influence the risk of PD. These two studies, PROGENI (PI: Tatiana Foroud; R01NS037167) and GenePD (PI: Richard Myers; R01NS036711) have been evaluating and recruiti...

phs000126.v1.p1 | EGA
TranscriptomicsTargeted degradation of sense and antisense C9orf72 RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia (strand specific RNA-seq)
Purpose: The purpose of this experiment is to identify expression changes after ASO-dependent depletion of mouse C9orf72 in the spinal cord of wild-type C57Bl/6 female mice. Methods: Strand specific RNA-seq was performed using RNAs extracted from spinal cord of C57Bl/6 mice two weeks after intracere...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-51685 | biostudies-arrayexpress
UnknownDeletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data.
Not available
S-EPMC4828586 | biostudies-literature
TranscriptomicsThe responses of astrocytes stimulated by extracellular a-synuclein
Abnormal neuronal aggregation of a-synuclein is implicated in the development of Parkinson’s disease. Glial cells also show extensive a-synuclein pathology and are thought to contribute to disease progression. However, the mechanism that produces the glial a-synuclein pathology and the interaction b...
ORGANISM(S): Rattus norvegicus 
2010-01-11 | E-GEOD-11574 | biostudies-arrayexpress
UnknownSpecifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's.
Not available
S-EPMC5244667 | biostudies-literature
UnknownLongitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.
Not available
S-EPMC10947001 | biostudies-literature
GenomicsGenome wide association scan in Parkinson's disease
Genome-wide association scan was performed in 1,705 cases of parkinson's genotyped on the Illumina Human 660W SNP array, and 5,175 controls genotyped on the Illumina1.2M-Duo. Analysis was carried out on the overlaps set of SNPs.
EGAS00000000034 | EGA
UnknownPrediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.
Not available
S-EPMC5761650 | biostudies-literature
ProteomicsIdentification of differentially expressed proteins in human pluripotent stem cell derived into dopaminergic neurons
Dopaminergic neurons located in the ventral midbrain can be broadly subdivided into two distinct subpopulations. Substantia nigra (SN) dopaminergic neurons are highly sensitive to toxic insults and selectively degenerate in Parkinson’s disease, while ventral tegmental area (VTA) dopaminergic neurons...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028639 | Pride
Pluripotent stem cells Dopaninergic neurons Parkinson disease 
UnknownSynaptic Loss in Primary Tauopathies Revealed by [<sup>11</sup> C]UCB-J Positron Emission Tomography.
Not available
S-EPMC7611123 | biostudies-literature
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