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MetabolomicsMetabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells
Genomic instability is one of the hallmarks of cancer. Several chemotherapeutic drugs and radiotherapy induce DNA damage to prevent cancer cell replication. Cells in turn activate different DNA damage response (DDR) pathways to either repair the damage or induce cell death. These DDR pathways also e...
2015-08-01 | MTBLS177 | MetaboLights
TranscriptomicsPARP inhibition
PARP inhibition and the effect on Arabidopsis thaliana high light tolerance
ORGANISM(S): Arabidopsis thaliana 
2012-05-01 | E-MTAB-896 | biostudies-arrayexpress
MetabolomicsTargeting SLC1A5-mediated glutamine metabolism overcomes PARP inhibitor resistance in ovarian cancer

Poly(ADP-ribose) polymerase inhibitors (PARPi), such as olaparib, have significantly improved outcomes in ovarian cancer (OC); however, therapy resistance remains a major clinical challenge. Here, we showed that glutamine metabolism was upregulated in PARPi-resistant OC cells and identified the g...

2026-04-08 | MTBLS14072 | MetaboLights
TranscriptomicsPARP-1, H3 and H3K4me3 ChIP-chip from MCF7 cells
We are examining the mechanisms by which the nuclear enzyme PARP-1 regulates gene expression. We performed ChIP-chip for PARP-1, histone H3 and H3K4me3 (lysine 4 trimethylation on histone H3) in MCF7 breast carcinoma cells, and looked at 23550 RefSeq genes to determine binding patterns of these fac...
ORGANISM(S): Homo sapiens 
2010-09-20 | E-GEOD-19619 | biostudies-arrayexpress
TranscriptomicsIGR_Michels_PARP
Non-small cell lung cancer (NSCLC) is often treated with cisplatin (CDDP). Here, we report that two distinct poly(ADP-ribose) polymerase (PARP) inhibitors exhibited a hyperadditive combination effect with CDDP to kill NSCLC cells. A majority of CDDP-resistant cell lines and clones exhibited constitu...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-MTAB-1353 | biostudies-arrayexpress
GenomicsSynergistic effects of PARP inhibition and cholesterol biosynthesis modulation
Synergistic effects of PARP inhibition and cholesterol biosynthesis modulation
PRJNA962032 | ENA
ProteomicsComprehensive selectivity profile of PARP inhibitors using a target-centric bead matrix
Explore selectivity of several PARP inhibitors against proteins of the PARP family.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044329 | Pride
Niraparib Parp Talazoparib Olaparib 
MetabolomicsThe Poly (ADP-Ribose) Polymerase inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
Breast tumors are characterized into different subtypes based on their surface marker expression, which affects their prognosis and treatment. For example, triple negative breast cancer cells (ER-/PR-/Her2-) show reduced susceptibility towards radiotherapy and chemotherapeutic agents. Poly (ADP-ribo...
2016-11-07 | MTBLS337 | MetaboLights
TranscriptomicsPARP_inhibition_transfer
Arabidopsis plants grown in vitro on control media on a nylon mesh; transfered after 7days either to control or 0.2mM 3-Methoxybenzamide (3MB) containing media were sampled after 24, 48, 96 and 168h to obtain data if/how PARP inhibition changes transcription of plants in respect to the observed grow...
ORGANISM(S): Arabidopsis thaliana 
2014-01-24 | E-MTAB-1466 | biostudies-arrayexpress
GenomicsLack of synergy between AR targeted therapies and PARP inhibition in homologous recombination- proficient prostate cancer
Lack of synergy between AR targeted therapies and PARP inhibition in homologous recombination- proficient prostate cancer
PRJNA1399478 | ENA
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