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MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
ProteomicsProteome-wide profiling of olaparib interactors using a biotinylated photoaffinity probe
Olaparib is a widely used PARP inhibitor for the treatment of BRCA-mutated cancers. To comprehensively understand the drug's clinical impact, measuring its interactions with intended on- and off-targets is crucial. In this study, olaparib's on- and off-targets were profiled using photoaffinity label...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD060372 | Pride
Parp inhibitors Photoaffinity labeling Chemical proteomics Olaparib 
TranscriptomicsIdentification of different gene expression levels in gastric cancer cell lines with drug treatment
A microarray time series was generated to identify which factor is expressed at different levels in two different gastric cancer cell lines, SNU 601 and SNU 668. These cell lines were treated for three different periods of time (24h, 48h, and 72h) with 1umol/L of olaparib or DMSO. Total RNA was extr...
ORGANISM(S): Homo sapiens 
2012-03-02 | E-MTAB-1012 | biostudies-arrayexpress
GenomicsOlaparib
Olaparib
PRJEB6685 | ENA
ProteomicsOlaparib based photo-affinity probes for PARP-1 detection in living cells
The poly-ADP-ribose polymerase (PARP) is a protein from the family of ADP-ribosyltransferases that catalyzes poly adenosine diphosphate ribose (ADPR) formation in order to attract the DNA repair machinery to DNA damage sites. Inhibition of PARP activity by olaparib can cause cell death which is of c...
ORGANISM(S): Homo sapiens (Human) 
2020-04-29 | PXD018661 | Pride
Olaparib  parp-1  bioorthogonal chemistry  chemical proteomics  photoaffinity probes 
ProteomicsExpression proteomic profiling of Olaparib in UWB1.289 cells
Explore protein abundance changes in UWB1.289 cells upon treatment with Olaparib
ORGANISM(S): Homo sapiens (Human) 
2024-05-13 | PXD046536 | Pride
Expression proteomics Parp Olaparib 
ProteomicsPhospho proteomic profiling of Olaparib in UWB1.289 cells
Explore phosphorylation changes in UWB1.289 cells upon treatment with Olaparib
ORGANISM(S): Homo sapiens (Human) 
2024-05-13 | PXD046613 | Pride
Expression proteomics Parp Olaparib 
ProteomicsExpression proteomic profiling of Niraparib and Olaparib
Explore protein abundance changes in several cancer cell lines upon treatment with Niraparib or Olaparib
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044333 | Pride
Expression proteiomics Niraparib Parp Olaparib 
ProteomicsDetermine PARP1 and PARP2 target engagment of Niraparib and Olaparib in live cells
Determine the target engagment of PARP inhibitors (Niraparib and Olaparib) to PARP1 and PAPR2 in live cells using isothermal dose-response experiments
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD044332 | Pride
Parp2 Parp1 Tpp Niraparib Itdr Olaparib 
ProteomicsOff-target profiling of Olaparib using Thermal Proteome Profiling
Explore off-targets of Olaparib using 2D Thermal Proteome Profiling (2D-TPP)
ORGANISM(S): Homo sapiens (Human) 
2024-05-13 | PXD046614 | Pride
Thermal proteome profiling Parp 2d-tpp Olaparib 
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