Niraparib - OmicsDI

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Metabolite Name

20-Hydroxy-N-arachidonoyltaurine (2)
3-(4-Hydroxy-2,2-dimethyl-1-oxo-3,3a-dihydroimidazo[1,2-a]indol-4-yl)-2-(4-oxoquinazolin-3-yl)propanoic acid (2)
Cylindrol A4 (2)
Niraparib (2)
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N-(1-Naphthyl)-N'-phenylthiourea (2)
1,3,4,5-Tetrahydrothiopyrano[4,3-b]indole (2)
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Lorazepam glucuronide (2)
N1,N5,N10-Tris-trans-p-coumaroylspermine (2)
Sufentanil (2)
Cepharadione B (2)

First Public Date

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Active, not recruiting (1)
Withdrawn (1)

Study type

Interventional (2)

Release Date

2025 (47)
2022 (47)
2023 (46)
2021 (39)
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2020 (24)
2019 (15)
2018 (14)
2017 (9)
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2014 (1)

Lab affiliation

Cellzome (7)
Moffitt Cancer Center Tampa, FL, USA (4)
Department of Laboratory Medicine and Pathology University of Minnesota School of Medicine (1)
Head of Proteomics & Metabolomics Facility (1)
Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA (1)

Publication date

2025 (11)
2026 (9)
2021 (8)
2024 (7)
2020 (1)
2022 (1)

Location

United States (1)

Keyword

Niraparib (2)
Niraparib metastatic colorectal cancer PARP1 PARP2 inhibitor (1)
Panitumumab (1)

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Off-target profiling of several PARP inhibitors using immobilized Niraparib beads

Explore additional off-targets of several PARP inhibitors using Niraparib beads

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD044330 | Pride

Expression proteomic profiling of Niraparib and Olaparib

Explore protein abundance changes in several cancer cell lines upon treatment with Niraparib or Olaparib

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD044333 | Pride

Expression proteiomics Niraparib Parp Olaparib

Determine PARP1 and PARP2 target engagment of Niraparib and Olaparib in live cells

Determine the target engagment of PARP inhibitors (Niraparib and Olaparib) to PARP1 and PAPR2 in live cells using isothermal dose-response experiments

ORGANISM(S): Homo sapiens (Human)

2025-05-13 | PXD044332 | Pride

Parp2 Parp1 Tpp Niraparib Itdr Olaparib

Off-target profiling of Niraparib and Olaparib using Thermal Proteome Profiling

Explore off-targets of Niraparib and Olaparib using 2D Thermal Proteome Profiling (2D-TPP)

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD044334 | Pride

Thermal proteome profiling Parp Niraparib 2d-tpp Olaparib

Live cell tracking of Niraparib off-targets using photo affinity labelling

Explore off-targets of Niraparib in live cells using photo affinity labelling (PAL)

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD044331 | Pride