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MetabolomicsMetabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess
Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks re...
2015-04-09 | MTBLS103 | MetaboLights
MetabolomicsTire wear particles drive a systemic bioenergetic collapse in Eisenia fetida via coupled barrier erosion and metabolic-immune deadlock

As global vehicular electrification accelerates, the exponential accumulation of tire wear particles (TWPs) poses a pervasive threat to edaphic ecosystems. To elucidate the systemic bioenergetic impact of TWP toxicity, we performed a non-targeted metabolomic profiling of the soil sentinel earthwo...

2026-07-07 | MTBLS14967 | MetaboLights
ProteomicsMass spectrometric characterization of HSV-1 L-particles from human dendritic cells and BHK21 cells and analysis of their functional role
Herpes simplex virus type 1 (HSV-1) is a very common human pathogenic virus among the world’s 12 population. The lytic replication cycle of HSV-1 is, amongst others, characterized by a tripartite viral 13 gene expression cascade, the assembly of nucleocapsids involving their subsequent nuclear egres...
ORGANISM(S): Mesocricetus auratus (Golden hamster) 
2021-09-09 | PXD020845 | Pride
Hsv-1 Light particles 9 t cell stimulation Mass spectrometry Immunomodulatory effect Heavy particles Bhk21 cells Dendritic cells 
ProteomicsMass spectrometric characterization of HSV-1 L-particles from human dendritic cells and BHK21 cells and analysis of their functional role Part B
Herpes simplex virus type 1 (HSV-1) is a very common human pathogenic virus among the world’s 12 population. The lytic replication cycle of HSV-1 is, amongst others, characterized by a tripartite viral 13 gene expression cascade, the assembly of nucleocapsids involving their subsequent nuclear egres...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020846 | Pride
Hsv-1 Light particles 9 t cell stimulation Mass spectrometry Immunomodulatory effect Heavy particles Bhk21 cells Dendritic cells 
ProteomicsProteomics analysis of human pre-40S ribosomal particles
Proteomics analysis of late human pre-40S particles purified using a catalytically-inactive RIO1 as bait. Analysis of RIO1(kd)-StHA pre-40S particles composition upon RPS26 depletion with siRNA.
ORGANISM(S): Homo sapiens (Human) 
2021-05-12 | PXD019270 | Pride
Ribosomal particles 
TranscriptomicsTranscription profiling of human cells transfected with MLV and HIV1 virus-like particles
We hypothesize that cellular mRNAs are incorporated nonselectively into retrovirus particles Experiment Overall Design: This study utilizes microarray analysis to test these hypotheses. Transfected cells were grown, RNA was isolated and used for global gene expression profiling (Affymetrix Human U13...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7213 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse inflammatory response to titanium dioxide particles exposure is enhanced during pregnancy
Rationale: Maternal immune responses can promote allergy development in offspring. Pilot data show that neonates of mother mice exposed during pregnancy to air pollution particles have increased allergic susceptibility. Objective: We investigated whether inflammatory response to titanium dioxide (Ti...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7475 | biostudies-arrayexpress
TranscriptomicsGene expression in circulating mononuclear cells after exposure to ultrafine carbon particles
Peripheral blood samples were collected before (0 hour) and at 24 hours after exposure from healthy subjects who participated in previous controlled exposures to ultrafine carbon particles (UFP, 50 microg/m3) or filtered air (FA)(n = 3 each). The exposure time was 2 hours. RNA from mononuclear cell ...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-19317 | biostudies-arrayexpress
TranscriptomicsINDUCTION OF OXIDATIVE STRESS AND METAL BINDING GENES IN HUMAN ALVEOLAR MACROPHAGES EXPOSED TO FINE PARTICLES
Exposure to particulate matter (PM) is consistently associated with increased morbidity and mortality attributable in part to respiratory illnesses. The alveolar macrophage (AM) is one of the cell types in the lung constantly exposed to and activated by ambient pollutants. Upon contact with environm...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-10394 | biostudies-arrayexpress
ProteomicsProteomics analysis of Tsr1-purified yeast pre-40S particles
Proteomics analysis of pre-40S ribosomal particles.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-03-09 | PXD016577 | Pride
Tsr1 Ribosome Pre-40s particles 
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