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ProteomicsMLKL PARylation sites were identified by LC-MSMS
To unravel the molecular mechanism involved in PARP1-mediated MLKL PARylation, the potential PARylation sites were identified in MLKL amino acid sequence by LC-MSMS.
ORGANISM(S): Homo sapiens (Human) 
2026-10-17 | PXD064394 | Pride
Lc-msms Mlkl Parylation sites 
ProteomicsPDHE1α, PARylation, Acetyl-CoA, Acetylation, Histones, DNA damage repair
Chromatin relaxation is a prerequisite step that allows the DNA repair machinery to access double-strand breaks (DSBs), and local histones around the DNA breaks suffer from prompt acetylation changes. However, an intriguing question remains as to where the large demands of acetyl-CoA is precisely pr...
ORGANISM(S): Homo sapiens (Human) 
2023-07-27 | PXD040676 | Pride
Pdhe1α Acetyl-coa Dna damage repair Parylation Histones Acetylation 
GenomicsCovalent PARylation of DNA base excision repair proteins regulates DNA demethylation
Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation
PRJNA702477 | ENA
UnknownSUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.
Not available
S-EPMC4388617 | biostudies-literature
OtherCovalent PARylation of DNA base excision repair proteins regulates DNA demethylation
Poly(ADP-ribose) polymerases (PARP1 and PARP2) contribute to DNA base excision repair (BER) and DNA demethylation and has been implicated in epigenetic programming in early mammalian development. Recently, proteomic analyses identified BER proteins to be covalently poly-ADP-ribosylated by PARPs. The...
ORGANISM(S): Mus musculus 
2023-11-08 | GSE166963 | GEO
UnknownPARylation of the forkhead-associated domain protein DAWDLE regulates plant immunity.
Not available
S-EPMC5283580 | biostudies-literature
ProteomicsA chromatin re-localization screen for the identification of Poly-ADP-ribosylation (PARylation)-dependent DNA repair factors.
A chromatin re-localization screen for the identification of Poly-ADP-ribosylation (PARylation)-dependent DNA repair factors.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045229 | Pride
Chromatin relocalization parylation screen 
ProteomicsPARG is Essential for Pol-theta-Mediated DNA End-Joining by Removing Repressive Poly-ADP Ribose Marks
DNA polymerase theta (Pol-theta)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Pol-theta is regulated at the molecular level to exert TMEJ remains unknown. We find that Pol-theta interacts with and is PARylated by PARP1 in vitro and in c...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092839 | MassIVE
OtherSUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.
Data from ProteomeXchange, PXD ID: PXD001681. File: RGP-HA-mSLX4-coIP-Control-1b.mzml. Published as part of EMBO Rep. 2015 Feb 26 . From the Abstract: {{i}} ... We report that the SLX4 nuclease scaffold protein is regulated by SUMOylation. We have identified three SUMO interaction motifs (SIMs) in ...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32310007055 | GPMDB
Resource Reanalysis 
UnknownCovalent PARylation of DNA base excision repair proteins regulates DNA demethylation.
Not available
S-EPMC10762122 | biostudies-literature
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