Parylation - OmicsDI

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Roderick O’Sullivan Ph.D., Dept. Pharmacology & Chemical Biology, University of Pittsburgh, UPMC Hillman Cancer Center, 5115 Centre Avenue Pittsburgh, PA 15213, USA (1)
KAUST Smart-Health Initiative(KSHI)and Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Jeddah, Saudi Arabia. Dept. of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, H3G1Y6, Canada. Rosalind & Morris Goodman Cancer Institute, McGill University, 1160 Pine Avenue, Montreal, QC, H3A1A3, Canada. (1)
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Department of Chemistry, Department of Molecular Biosciences, and the Chemistry of Life Processes Institute, Northwestern University, Evanston, IL USA 60208 (1)
Dr. Shilpee Dutt, Ph.D., Principal Investigator, Scientific Officer 'G', TMC-ACTREC (1)
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands. (1)
junzh128@szu.edu.cn (1)
Organismal and Evolutionary Biology Research Programme, Faculty of Biological and Environmental Sciences, and Viikki Plant Science Center, University of Helsinki, Helsinki, Finland (1)
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen (1)
Departement of Molecular Mechanisms of Disease, University of Zurich, Winterthurstrasse 190, 8057 Zurich, Switzerland (1)
University of Copenhagen, Department of Cellular and Molecular Medicine, Center for Gene expression, Blegdamsvej 3B, 2200 Copenhagen, Denmark (1)
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Laboratory of Paediatrics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands (1)
Proteomics Facility, IZKF Aachen, University Clinic RWTH Aachen (1)
Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China (1)
Vanderbilt University, Proteomics Core (1)
Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, China (1)
CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. (1)
Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea (1)
University of Pennsylvania, Biochemistry & Biophysics, Philadelphia, PA, 19104, USA (1)

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Transposon screen for PARylation targets

PRJEB26343 | ENA

Identification of poly(ADP-ribosyl)ation targets reveals a role of DAWDLE in Arabidopsis immunity

Our stardy uncovers many previously unknown PARylation targets and points to the distinct functions of small RNA biogenesis respectively

ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress)

2018-10-27 | PXD004267 | Pride

PARylation of UBC13 and PDI proteins

NH2OH was used to remove PAR from the PARylated proteins. This treatment left on the PARylated residues a hydroxamic acid derivative, which has a signature mass increase of +15.0109 Da and could be distinguished by mass spectrometry.

ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702)

2021-07-23 | MSV000087876 | MassIVE

PDHE1α, PARylation, Acetyl-CoA, Acetylation, Histones, DNA damage repair

Chromatin relaxation is a prerequisite step that allows the DNA repair machinery to access double-strand breaks (DSBs), and local histones around the DNA breaks suffer from prompt acetylation changes. However, an intriguing question remains as to where the large demands of acetyl-CoA is precisely pr...

ORGANISM(S): Homo sapiens (Human)

2023-07-27 | PXD040676 | Pride

Pdhe1α Acetyl-coa Dna damage repair Parylation Histones Acetylation

Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation

PRJNA702477 | ENA

PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination

PRJNA753878 | ENA

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

Not available

S-EPMC5964205 | biostudies-literature

Tankyrase1/2 inhibition reveals that PARylation is regulating aerobic activities in hepatocytes and HepG2 cells

XAV-939 is an anti-oncogenic small molecule that potently inhibits tankyrase1/2 (TNKS1/2), thereby blocking protein poly ADP-ribosylation (PARylation) of pleiotropic protein targets. In the present study, XAV-939 was used to explore its potential for improving human-derived liver models in vitro. Ep...

ORGANISM(S): Homo sapiens (Human)

2024-07-25 | PXD045988 | Pride

Human Dia hrms1 Tankyrase Ip Parylation

A chromatin re-localization screen for the identification of Poly-ADP-ribosylation (PARylation)-dependent DNA repair factors.

ORGANISM(S): Homo sapiens (Human)

2024-01-26 | PXD045229 | Pride

Chromatin relocalization parylation screen

Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation

Poly(ADP-ribose) polymerases (PARP1 and PARP2) contribute to DNA base excision repair (BER) and DNA demethylation and has been implicated in epigenetic programming in early mammalian development. Recently, proteomic analyses identified BER proteins to be covalently poly-ADP-ribosylated by PARPs. The...

ORGANISM(S): Mus musculus

2023-11-08 | GSE166963 | GEO

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472 Results

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