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UnknownA Sterol-PI(4)P exchanger modulates the Tel1/ATM axis of the DNA Damage Response
Not available
S-SCDT-10_15252-EMBJ_2022112684 | biostudies-other
TranscriptomicsCohesin association to replication sites depends on Rad50 and promotes fork restart
The cohesin complex holds together newly-replicated chromatids and is involved in diverse pathways that preserve genome integrity. We show that in budding yeast, cohesin is transiently recruited to active replication origins and it spreads along DNA as forks progress. When DNA synthesis is impeded, ...
ORGANISM(S): Saccharomyces cerevisiae W303 
2012-10-01 | E-GEOD-39078 | biostudies-arrayexpress
TranscriptomicsEssential Roles of the Smc5/6 complex in Replication through Pausing Sites and Endogenous DNA Damage Tolerance
The essential functions of the conserved Smc5/6 complex remain elusive. To uncover its roles in genome maintenance, we established Saccharomyces cerevisiae cell cycle-regulated alleles that enable restriction of Smc5/6 components to S or G2/M. Unexpectedly, the essential functions of Smc5/6 segregat...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-19 | E-GEOD-72241 | biostudies-arrayexpress
GenomicsSenataxin resolves R-loops forming at DNA double strand breaks to prevent translocations
DNA Double Strands Breaks (DSBs) are highly detrimental since they can lead to mutations and chromosomes rearrangements (amplification, deletion, translocation and chromosome loss). Here, we set to assess the role of senataxin, a RNA:DNA helicase involved in the regulation of transcription and the m...
ORGANISM(S): Homo sapiens 
2018-02-20 | E-MTAB-6318 | biostudies-arrayexpress
UnknownProminent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes.
Not available
S-EPMC12795280 | biostudies-literature
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