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ProteomicsPatch-Clamp Proteomics of Single Neurons in Tissue Using Electrophysiology and Subcellular Capillary Electrophoresis Mass Spectrometry
In this project, we enabled mass spectrometry based proteomics characterization of single neurons in sections of the mouse brain. We accessed cells in a whole-cell patch clamp configuration and aspirated a portion of the neuronal soma into the patch clamp probe. The collected aspirate was expelled ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-18 | PXD028040 | Pride
Electrophysiology Mass spectrometry Nervous system Bottom-up proteomics Capillary electrophoresis Whole-cell patch-clamp Mouse 
TranscriptomicsAtopic Eczema expression profiling, Saaf_2008
Background: Atopic eczema (AE) is a common chronic inflammatory skin disorder. In order to dissect the genetic background several linkage and genetic association studies have been performed. Yet very little is known about specific genes involved in this complex skin disease, and the underlying molec...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12511 | biostudies-arrayexpress
TranscriptomicsSerpinb3a contributes to early skin inflammation following allergen exposure
Serpinb3a knockout mice show attenuated Transepidermal Water Loss (TEWL) and S100A8 expression (an early inflammatory marker) following treatment with Aspergillus fumigatus extract. The aim of the RNAseq experiments was to provided mechanistic insight for the role of Serpinb3a by identifying early d...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-54640 | biostudies-arrayexpress
ProteomicsThe kidney releases in the urine and circulation a non-polymerizing form of Uromodulin that retains the external hydrophobic patch domain
Uromodulin (Tamm-Horsfall protein, THP) is a glycoprotein uniquely produced in the kidney. It is released by cells of the thick ascending limbs (TAL) apically in the urine, and basolaterally in the renal interstitium and systemic circulation. Processing of mature urinary THP, which polymerizes into ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD027914 | Pride
Uromodulin Lc-msms Aki External hydrophobicpatch domain Urine Serum Elisa Human 
UnknownA Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development.
Not available
S-EPMC10454728 | biostudies-literature
UnknownPharmacokinetics, safety and tolerability of rotigotine transdermal patch in healthy Japanese and Caucasian subjects.
Not available
S-EPMC3899448 | biostudies-literature
UnknownSex differences in patch-leaving foraging decisions in rats.
Not available
S-EPMC11003400 | biostudies-literature
UnknownProtocol for a multicentre prehospital randomised controlled trial investigating tranexamic acid in severe trauma: the PATCH-Trauma trial.
Not available
S-EPMC7970250 | biostudies-literature
ProteomicsAn intrinsically disordered region of histone demethylase KDM5A regulates catalysis through interactions with the nucleosomal acidic patch and DNA
KDM5A lysine demethylase conformation was probed by BS3 crosslinking in the presence and absence of DNA. Crosslinked proteins were reduced, alkylated with iodoacetamide, trypsin digest, and labeled with TMT6plex reagent prior to mixing and acquisition on an Orbitrap Exploris equiped with a FAIMS sou...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-10 | MSV000097094 | MassIVE
UnknownThe Nictavi Tarsus Patch: A New Device for Achieving Temporary Eyelid Closure in Lagophthalmos.
Not available
S-EPMC10327908 | biostudies-literature
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