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Nucleus is a highly structured organelle and contains many functional compartments. While the structural basis for this complex spatial organization of compartments is unknown, a major component of this organization is likely to be the non-chromatin scaffolding called nuclear matrix (NuMat). Exp...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2011-05-05 | PRD000255 | Pride
Spt6 is a multifunctional histone chaperone involved in the maintenance of chromatin structure during elongation by RNA polymerase II (Pol II). Spt6 has a tandem SH2 (tSH2) domain within its C-terminus that recognizes Pol II CTD peptides phosphorylated on Ser2, Ser5 or Try1 in vitro. Deleting the tS...
ORGANISM(S): Saccharomyces cerevisiae 
During open mitosis chromatin condenses to form chromosomes and decondenses post-mitotically to re-occupy their designated nuclear territory in a precisely lineage specific manner. This necessitates that features of nuclear architecture persist through mitosis. Here we present a proteomic study, whi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-07-17 | PXD008404 | Pride
Eukaryotic genome is compartmentalized into structural and functional domains. One of the concepts of higher order organization of chromatin posits that the DNA is organized in constrained loops that behave as independent functional domains. A predominantly ribo-proteinaceous nucleoskeleton, termed ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-25 | PXD031279 | Pride
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