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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsExpression profiling during arabidopsis/downy mildew interaction reveals a highly-expressed effector that attenuates responses to salicylic acid.
Plants have evolved strong innate immunity mechanisms, but successful pathogens evade or suppress plant immunity via effectors delivered into the plant cell. Hyaloperonospora arabidopsidis (Hpa) causes downy mildew on Arabidopsis thaliana, and a genome sequence is available for isolate Emoy2. Here, ...
ORGANISM(S): Arabidopsis thaliana 
2014-11-21 | E-GEOD-53641 | biostudies-arrayexpress
ProteomicsSystematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
Pathogens deploy effector proteins to exploit host cell biology, yet most pathogen open reading frames (ORFs) are rapidly evolving and lack functional annotation. To address this, we developed the eORFeome, a scalable functional genomics platform encompassing 3,835 effector ORFs from diverse viruses...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD078568 | Pride
Pathogens Functional genomics Human signalling pathways Effectors Host-pathogen interaction Orfeome High-throughput screening 
GenomicsSystematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways
PRJNA1482054 | ENA
TranscriptomicsExpression profiling of Col-0 and rps2 treated with Psm:AvrRpt2
Identification of differential gene expression during RPS2-mediated effector-triggered immunity in Arabidopsis Four-week-old leaves of Arabidopsis Col-0 wild type and rps2 mutant plant were infiltrated with Pseudomonas syringae pv. Maculicola carring effector AvrRpt2 at OD 0.01. Samples were collect...
ORGANISM(S): Arabidopsis thaliana 
2016-09-01 | E-GEOD-72742 | biostudies-arrayexpress
ProteomicsIdentification of interactors of AtNRG1B after treatment with Pfo carrying avrRps4 effector
NRG1.2 is a helper NLR required for RRS1 RPS4 mediated immunity. RPS4 recognizes effector avrRps4 from pathogen P. syringae leading to hypersensitive response and immunity. here we co-immunoprecipitate NRG1.2-HF to identify interacting proteins upon effector recognition
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-04-07 | PXD022907 | Pride
Immunity Co-immunoprecipitation Arabidopsis Effector Nlr 
MetabolomicsDecreased abundance of type III secretion systeminducing signals in Arabidopsis mkp1 enhances resistance against Pseudomonas syringae
Genes encoding the virulence-promoting type III secretion system (T3SS) in phytopathogenic bacteria are induced at the start of infection, indicating that recognition of signals from the host plant initiates this response. However, the precise nature of these signals and whether their concentrations...
2014-06-24 | MTBLS95 | MetaboLights
ProteomicsCombination of in-vivo proximity labeling and co-immunoprecipitation identifies the host target network of a tumor-inducing effector in the fungal maize pathogen Ustilago maydis
Plant pathogens secrete effectors, which target host proteins to facilitate infection. The Ustilago maydis effector UmSee1 is required for tumor formation in the leaf during infection of maize. UmSee1 interacts with maize SGT1 and blocks its phosphorylation in-vivo. In the absence of UmSee1, U. mayd...
ORGANISM(S): Zea mays (Maize) 
2023-10-24 | PXD040939 | Pride
Zea mays Turboid Effector Ustilago maydis Plant-pathogen interaction 
ProteomicsSts2, a transcriptional activator effector of Ustilago maydis, regulates hyperplasia in maize during pathogen-induced tumor formation
Ustilago maydis causes common smut in maize, which is characterized by tumor formation in aerial parts of maize. Tumor comes from the de novo cell division of highly developed bundle sheath and subsequent cell enlargement. However, its mechanism is still unknown. Here, we characterize the U. maydis ...
ORGANISM(S): Zea mays (Maize) 
2023-10-12 | PXD040350 | Pride
Ustilago maydis Bundle sheath Transcriptional activator Hyperplasia tumor Leaf developmental regulator 
TranscriptomicsGene expression in LCMV-specific Blimp-1 deficient effector CD8+ T cells compared to wildtype effector CD8+ T cells
Antigen-specific effector CD8+ T cells deficient in Blimp-1 (Prdm1) do not acquire maximal effector functions, evade terminal differentiation, and more rapidly acquire some hallmark properties of memory CD8+ T cells. In this study, we compared the gene expression profiles of wildtype and Prdm1-/- LC...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-17211 | biostudies-arrayexpress
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