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MetabolomicsA Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato
In response to biotic stress, plants produce suites of highly modified fatty acids that bear unusual chemical functionalities. Despite their chemical complexity and proposed roles in pathogen defense, little is known about the biosynthesis of decorated fatty acids in plants. Falcarindiol is a protot...
2022-01-17 | MTBLS1039 | MetaboLights
MetabolomicsA Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection
The potential for commensal microorganisms indigenous to a host (the microbiome or microbiota) to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics systems approach, incorporating proteomics, metabolomics, glycomics, and metagenomics, to explore...
2014-06-24 | MTBLS96 | MetaboLights
MetabolomicsMulti-omics analysis of Arabidopsis leaves upon infection by necrotrophic pathogen Botrytis cinerea

Botrytis cinerea is a necrotrophic pathogen that induces host cell death, causing substantial economic losses in agriculture. In this study, we show that functional depletion of INOSITOL AUXOTROPHY 80 (INO80), a nuclear factor involved in local chromatin remodeling, reduces the susceptibility of ...

2026-03-09 | MTBLS12467 | MetaboLights
MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
MetabolomicsComparing Campylobacter jejuni to three other enteric pathogens in OligoMM 12 mice reveals pathogen-specific host and microbiota responses
Campylobacter jejuni, non-typhoidal Salmonella spp., Listeria monocytogenes and enteropathogenic/enterohemorrhagic Escherichia coli (EPEC/EHEC) are leading causes of food-borne illness worldwide. Citrobacter rodentium has been used to model EPEC and EHEC infection ...
2025-02-25 | MTBLS11078 | MetaboLights
MetabolomicsLipids in the escalated host-pathogen arms race

Lipids, fundamental constituents of cell membranes, cellular energy carriers, and signaling molecules, play a pivotal role in the interaction between pathogens and hosts. During microbial infections, lipids not only fuel the activation of the immune system but also, acting as signaling molec...

2025-07-05 | MTBLS12678 | MetaboLights
MetabolomicsHeat drives tomato bacterial wilt through enhanced pathogen virulence and rhizosphere microbiome and metabolic shifts
Bacterial wilt caused by Ralstonia solanacearum is globally widespread and strongly associated with elevated temperature, yet the ecological mechanisms underlying temperature-driven disease outbreaks remains unclear. Here, we show that high temperature promotes bacterial wilt by reconfiguring the to...
2026-05-31 | MTBLS14437 | MetaboLights
MetabolomicsTime-resolved decoding of metabolic signatures of in vitro growth of the hemibiotrophic pathogen Colletotrichum sublineolum
Metabolomics has emerged as a powerful approach to comprehensively interrogate cellular biochemistry. As such, we applied an untargeted liquid chromatography-mass spectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotrophic sorghum pathogen, Colletotric...
2022-05-30 | MTBLS735 | MetaboLights
MetabolomicsDual transcriptomic & metabolomic analysis of elicited flax sheds light on the kinetics of immune defense activation against the biotrophic pathogen Oidium lini.
Flax (Linum usitatissimum) grown under controlled conditions displayed genotype-dependent resistance to powdery mildew (Oidium lini) following COS-OGA (comprising chitosan- and pectin-derived oligomers) elicitor application. The present study reveals a two-step immune response in plant...
2025-04-25 | MTBLS8263 | MetaboLights
ProteomicsOrientia tsutsugamushi proteome profile host context
Emerging and neglected pathogens pose challenges as their biology is frequently poorly understood, and genetic tools often do not exist to manipulate them. Organism agnostic sequencing technologies offer a promising approach to understand the molecular processes underlying these diseases. Here we ap...
ORGANISM(S): Cellular Organisms 
PXD017956 | JPOST Repository
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