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TranscriptomicsThe responses of astrocytes stimulated by extracellular a-synuclein
Abnormal neuronal aggregation of a-synuclein is implicated in the development of Parkinson’s disease. Glial cells also show extensive a-synuclein pathology and are thought to contribute to disease progression. However, the mechanism that produces the glial a-synuclein pathology and the interaction b...
ORGANISM(S): Rattus norvegicus 
2010-01-11 | E-GEOD-11574 | biostudies-arrayexpress
ProteomicsEndogenous alpha-synuclein is essential for the transfer of pathology by exosomes, following PFF inoculation in vivo.
Alpha-Synuclein (α-Syn) association with exosomes has been extensively studied both as a physiological process but also as a means of disease transmission under pathological conditions, via an elusive mechanism. Here, we utilized the preformed fibril (PFF) mouse model, as a source of brain-derived e...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-04 | PXD036301 | Pride
Pathology transmission Exosomes Alpha-synuclein (α-syn) Spreading Parkinson’s disease Pff 
Methylation profilingEpigenetic Transgenerational Inheritance of Parent-of-Origin Allelic Transmission of Outcross Pathology and Sperm Epimutations Following Ancestral Toxicant Exposures
Previous observations have demonstrated that the agricultural fungicide vinclozolin and the pesticide DDT (dichlorodiphenyltrichloroethane) induce transgenerational sperm epimutations involving DNA methylation. These two environmental toxicants were used to investigate the impacts of parent-of-origi...
ORGANISM(S): Rattus norvegicus 
2019-07-23 | GSE130258 | GEO
GenomicsEpigenetic Transgenerational Inheritance of Parent-of-Origin Allelic Transmission of Outcross Pathology and Sperm Epimutations Following Ancestral Toxicant Exposures
Epigenetic Transgenerational Inheritance of Parent-of-Origin Allelic Transmission of Outcross Pathology and Sperm Epimutations Following Ancestral Toxicant Exposures
PRJNA534495 | ENA
GenomicsCharacterizing the Immune Infiltrates in Secondary Syphilis: Implications for Transmission and Pathology
Characterizing the Immune Infiltrates in Secondary Syphilis: Implications for Transmission and Pathology
PRJNA1237298 | ENA
UnknownHunting coronavirus by transmission electron microscopy - a guide to SARS-CoV-2-associated ultrastructural pathology in COVID-19 tissues.
Not available
S-EPMC7537546 | biostudies-literature
TranscriptomicsTranscription profiling of Salmonella enterica serotype SL1344 wildtype, pSf-R27sfh and pSf-R27 at stationary and exponential growth phases, to investigate the role of the Sfh protein encoded by transmissible plasmids and involved in human typhoid
The Sfh protein is encoded by self-transmissible plasmids involved in human typhoid and is closely related to the global regulator H-NS. We have found that Sfh provides a stealth function that allows the plasmids to be transmitted to new bacterial hosts with minimal effects on their fitness. Introdu...
ORGANISM(S): Salmonella enterica serotype Typhimurium 
2007-01-15 | E-SGRP-7 | biostudies-arrayexpress
UnknownTau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice.
Not available
S-EPMC7845573 | biostudies-literature
UnknownEpigenetic transgenerational inheritance of parent-of-origin allelic transmission of outcross pathology and sperm epimutations.
Not available
S-EPMC6987017 | biostudies-literature
GenomicsIntrauterine SARS-CoV-2 transmission
Hereby, we report a confirmed case of intrauterine SARS-CoV-2 transmission with rapid placental dysfunction and fetal distress.
PRJEB40434 | ENA
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