Patient derived xenografts (pdx)

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Unknown (782)
Genomics (385)
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Homo sapiens (314)
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Organisms

Homo sapiens (221)
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Cell culture (6)
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Disease

Breast cancer (9)
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Technology Type

Mass Spectrometry (40)
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Mass spectrometry (3)
Illumina HiSeq 2000, ILLUMINA (2)
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Instrument Platform

Q Exactive (8)
Illumina NovaSeq 6000 (6)
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Illumina HiSeq 2500 (4)
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2023 (29)
2026 (28)
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2015 (16)
2016 (15)
2018 (12)
2014 (5)
2013 (2)
2011 (1)

CHEBI ID

CHEBI:61040 (1)
CHEBI:190598 (1)
CHEBI:39065 (1)
CHEBI:84324 (1)
CHEBI:191252 (1)
CHEBI:133649 (1)
CHEBI:133647 (1)
CHEBI:142440 (1)
CHEBI:165539 (1)
CHEBI:17586 (1)
CHEBI:26008 (1)
CHEBI:166485 (1)
CHEBI:132546 (1)
CHEBI:15873 (1)
CHEBI:183109 (1)
CHEBI:133223 (1)
CHEBI:137271 (1)
CHEBI:604731 (1)
CHEBI:145755 (1)
CHEBI:165864 (1)
CHEBI:70961 (1)
CHEBI:133032 (1)
CHEBI:68505 (1)
CHEBI:133559 (1)
CHEBI:73051 (1)
CHEBI:74990 (1)
CHEBI:15245 (1)
CHEBI:16163 (1)
CHEBI:133733 (1)
CHEBI:133677 (1)

Metabolite Name

Bicine (1)
Cyano-alanine (1)
Cytidine 2',3'-cyclic monophosphate (1)
Alpha-hydroxycaproate (1)
2-hydroxynervonate* (1)
Unkown (1)
2-hydroxybehenate (1)
Stearoylcholine* (1)
1-palmitoyl-2-oleoyl-GPI (16:0/18:1)* (1)
Dimethyl sulfone (1)
Gamma-glutamyltryptophan (1)
Genistein (1)
Beta-muricholate (1)
7-ketodeoxycholate (1)
2-hydroxyoctanoate (1)
Taurodeoxycholate (1)
S-(1,2-dicarboxyethyl)glutathione (1)
N-linoleoyltaurine* (1)
N,N-dimethylalanine (1)
Linoleoylcholine* (1)
CoA-glutathione* (1)
2,4-di-tert-butylphenol (1)
Biopterin (1)
3-hydroxymyristate (1)
1-oleoyl-GPI (18:1) (1)
Spermine (1)
Pyrraline (1)
N1,N12-diacetylspermine (1)
Lyxonate (1)
Indoleacetate (1)

First Public Date

2024 (40)
2023 (39)
2025 (38)
2020 (38)
2022 (33)
2026 (30)
2021 (28)
2017 (18)
2018 (15)
2019 (14)
2016 (10)
2015 (6)
2014 (2)

Study status

Recruiting (2)

Study type

Transcription profiling by array (23)
RNA-seq of coding RNA (20)
Human - High-throughput sequencing (4)
Methylation profiling by array (4)
RNA-seq of coding RNA from single cells (3)
Genotyping by array (2)
Observational (2)
Unknown experiment type (1)
Human - One-color microarray (1)
Cell line - High-throughput sequencing (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
Comparative genomic hybridization by array (1)
ATAC-seq (1)
ChIP-seq (1)
Proteomic profiling by array (1)
RNA-seq of total RNA (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (110)
2021 (100)
2020 (100)
2023 (89)
2024 (74)
2018 (69)
2019 (67)
2025 (66)
2017 (60)
2016 (44)
2015 (36)
2014 (16)
2026 (14)
2013 (3)
2011 (1)

Lab affiliation

1Lester and Sue Smith Breast Center and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA (1)
Baylor College of Medicine (1)
Breast Center - Lewis, Baylor College of Medicine, Houston TX US (1)
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. (1)
Cancer Research UK University of Cambridge Li Ka Shing Centre Robinson Way Cambridge, CB2 0RE (1)
Cell Signalling & Proteomics Group, Barts Cancer Institue, Queen Mary University of London, London, UK (1)
Chair Quantitative Proteomics Director Proteome Center Tuebingen Interfaculty Institute for Cell Biology University of Tuebingen Auf der Morgenstelle 15 72076 Tuebingen Germany (1)
Clinical Research Division, Fred Hutchinson Cancer Reseaarch Center (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States (1)
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark (1)
Department of Drug Design and Pharmacology. University of Copenhagen. Denmark (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, MN 55905 USA (1)
Department of Medical Biotechnology and Laboratory Science College of Medicine, Chang Gung University, Taoyuan, Taiwan (1)
Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, Buffalo, New York, United States (1)
Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford School of Medicine Stanford University (1)
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland (1)
German Cancer Research Center, Heidelberg (1)
Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000 Leuven, Belgium / Department of Obstetrics and Gynecology, University Hospitals Leuven and Department of Oncology, 3000 Leuven, Belgium / Centre for Gynecologic Oncology Amsterdam (CGOA), Antoni Van Leeuwenhoek-Netherlands Cancer Institute (AvL-NKI), University Medical Center (UMC), Amsterdam, The Netherlands (1)
Head of the Curie Institute Mass Spectrometry Platform (1)
Hospital for Sick Children, Toronto, Ontario, Canada (1)
Immunology Department, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland (1)
Indiana University School of Medicine, Dept of Pediatrics; Herman B Wells Center for Pediatric Research (1)
Johns Hopkins University (1)
Lund University (1)
MaxPlanck Institute of Biochemistry (1)
Molecular Genetics, University of Toronto Hospital for Sick Children, Toronto, Canada (1)
National Institute for Cellular Biotechnology, Dublin City University (1)
Novo Nordisk Foundation Center for Protein Research Proteomics Program University of Copenhagen Faculty of Health and Medical Sciences Blegdamsvej 3b DK-2200 Copenhagen Denmark (1)

Location

Japan (2)

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Genomic profiling of patient-derived xenografts identify high level â€œpassengerâ€ gene aberrations associated with better prognosis in non-small cell lung cancer

Patient-derived tumor xenografts (PDXs) increasingly are being used as preclinical models to study human cancers and to evaluate novel therapeutics, as they reflect clinical cancers more closely than established tumor cell lines. With >100 PDXs established from resected non-small cell lung carcinoma...

ORGANISM(S): Mus musculus

2016-10-26 | E-GEOD-68929 | biostudies-arrayexpress

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

Resistance to androgen deprivation therapies leads to metastatic castration-resistant prostate cancer (mCRPC) of adenocarcinoma (AdCa) origin that can transform to emergent aggressive variant prostate cancer (AVPC) which has neuroendocrine (NE)-like features. To this end, we used LuCaP patient-deriv...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-06-09 | MSV000092139 | MassIVE

Illumina Infinium HumanMethylation EPIC Profiling of paediatric diffuse type high grade gliomas and patient derived xenografts

Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.

ORGANISM(S): Homo sapiens

2026-03-31 | E-MTAB-16762 | biostudies-arrayexpress

Illumina Infinium HumanMethylation 450k Profiling of paediatric diffuse type high grade gliomas and patient derived xenografts

Methylation array based profiling of paediatric diffuse type high grade glioma primary tumours and patient derived orthotropic xenografts (PDX) in mice.

ORGANISM(S): Homo sapiens

2026-03-31 | E-MTAB-16763 | biostudies-arrayexpress

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2023-06-09 | MSV000092137 | MassIVE

Microarray gene expression analysis of primary EWS and OS tumors and corresponding Patient Derived Xenografts (PDX)

Osteosarcoma (OS) and Ewing’s sarcoma (EW) are the two most common pediatric solid tumors, after brain tumors. Multimodal treatments have significantly improved prognosis in localized disease but outcome is still poor in metastatic patients, for whom therapeutic options are often inadequate. Preclin...

ORGANISM(S): Homo sapiens

2019-08-27 | E-MTAB-7568 | biostudies-arrayexpress

Tyrosine phosphoproteomics of patient-derived xenografts reveals ephrin type-B receptor 4 tyrosine kinase as novel therapeutic target in pancreatic cancer

Pancreatic ductal adenocarcinoma is a recalcitrant tumor with minimal response to conventional chemotherapeutic approaches. Oncogenic signaling by activated tyrosine kinases has been implicated in cancers resulting in activation of diverse effector signaling pathways. Thus, discovery of aberrantly a...

ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human)

2021-05-24 | PXD021729 | Pride

SNP profiling of pancreatic adenocarcinoma (PDAC) xenografts

Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies and a major health problem. Patient-derived xenografts (PDX) are appearing as a prime approach for preclinical studies despite being insufficiently characterized as a model of the human disease and its diversity. We genera...

ORGANISM(S): Homo sapiens

2017-12-12 | E-MTAB-5006 | biostudies-arrayexpress

Whole transcriptome profiling of 79 patient derived xenograft (PDX) models

RNA-Seq and a species-specific mapping strategy were used to profile the human and mouse transcriptomes of tumour samples taken from 79 PDX models representing multiple cancer types (19 x breast, 37 x lung, 8 x colorectal, 7 x ovarian, 3 x endometrial, 2 x pancreatic, 2 x ampullary, 1 x leukaemia).

ORGANISM(S): Mus musculus

2016-03-01 | E-MTAB-3980 | biostudies-arrayexpress

Proteomics of prostate cancer patient derived xenografts

A set of 17 prostate cancer patient-derived xenografts (PDX, Lin et al 2014, Cancer research) was analyzed by mass spectrometry-based proteomics to characterize the effects of castration in vivo, and the proteome differences between NEPC and prostate adenocarcinomas.

ORGANISM(S): Homo sapiens (Human)

2019-09-11 | PXD009636 | Pride

Prostate cancer neuroendocrine nepc castration crpc pdx lc-ms7ms

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