Patient-derived xenograft models (pdx)

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Organisms

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Human alphaherpesvirus 1 strain 17 (45)
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Mus musculus (33)
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Homo sapiens/Mus musculus xenograft (1)
Mus (1)

Organisms

Homo sapiens (344)
Mus musculus (15)
Canis lupus familiaris (2)
Homo sapiens/Mus musculus xenograft (1)
Mus (1)

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Cell culture (13)
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Disease

Breast cancer (7)
Malignant neoplasm of ovary (6)
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Neuroblastoma (1)
Non-small cell lung carcinoma (1)
Oral squamous cell carcinoma (1)
Pancreatic ductal carcinoma (1)
Triple-receptor negative breast cancer (1)

Technology Type

Mass Spectrometry (46)
Shotgun proteomics (21)
Bottom-up proteomics (16)
Data-dependent acquisition (6)
Affinity purification coupled with mass spectrometry proteomics (5)
Top-down proteomics (4)
Mass spectrometry (3)
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Illumina HiSeq 2000, ILLUMINA (2)
Infinium_OmniExpress-24v1.0 (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Mass spectrometry assay (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
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Instrument Platform

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PC (1)
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BD FACSARIA II (1)
Illumina NovaSeq X (1)
Orbitrap Eclipse (1)
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Q Exactive HF (1)
Liquid Chromatography MS - alternating - hilic (1)
Liquid Chromatography MS - negative (1)
Liquid Chromatography MS - positive (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - positive - hilic (1)
LTQ Orbitrap Velos (1)

Publication Date

2026 (58)
2025 (58)
2023 (56)
2024 (51)
2021 (40)
2022 (36)
2020 (24)
2016 (17)
2015 (16)
2019 (12)
2014 (9)
2017 (7)
2018 (5)
2013 (4)

CHEBI ID

CHEBI:61040 (1)
CHEBI:193556 (1)
CHEBI:37755 (1)
CHEBI:70961 (1)
CHEBI:166485 (1)
CHEBI:191252 (1)
CHEBI:133649 (1)
CHEBI:133647 (1)
CHEBI:137271 (1)
CHEBI:84153 (1)
CHEBI:15245 (1)
CHEBI:89188 (1)
CHEBI:142440 (1)
CHEBI:176456 (1)
CHEBI:77042 (1)
CHEBI:165864 (1)
CHEBI:145755 (1)
CHEBI:84324 (1)
CHEBI:133693 (1)
CHEBI:133677 (1)
CHEBI:133672 (1)
CHEBI:84814 (1)
CHEBI:78266 (1)
CHEBI:78268 (1)
CHEBI:165856 (1)
CHEBI:74532 (1)
CHEBI:183109 (1)
CHEBI:165872 (1)
CHEBI:132188 (1)
CHEBI:133186 (1)

Metabolite Name

Cyano-alanine (1)
Unkown (1)
Betaine aldehyde (1)
N6,N6,N6-trimethyllysine (1)
Thymidine 5'-monophosphate (1)
Histidine methyl ester (1)
2-hydroxysebacate (1)
Ethyl beta-glucopyranoside (1)
Linoleoylcholine* (1)
Stearoylcholine* (1)
1-palmitoyl-2-oleoyl-GPI (16:0/18:1)* (1)
1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)* (1)
1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)* (1)
1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4)* (1)
3-hydroxypyridine sulfate (1)
Guaiacol sulfate (1)
Lanthionine (1)
S-methylcysteine sulfoxide (1)
1-linoleoyl-GPI (18:2)* (1)
Pyrraline (1)
4-ethylphenylsulfate (1)
N1-Methyl-4-pyridone-3-carboxamide (1)
N1-methylinosine (1)
Genistein (1)
7-ketodeoxycholate (1)
Indoleacetate (1)
3-hydroxymyristate (1)
1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) (1)
Biopterin (1)
Isoleucylhydroxyproline* (1)

First Public Date

2026 (83)
2025 (68)
2024 (68)
2023 (53)
2022 (43)
2021 (38)
2020 (30)
2019 (22)
2016 (11)
2017 (10)
2015 (10)
2018 (9)
2014 (7)

Modification

-17.026549 (1)
15.994915 (1)
42.010565 (1)

Study status

Recruiting (1)

Study type

Transcription profiling by array (23)
RNA-seq of coding RNA (12)
Human - High-throughput sequencing (3)
Methylation profiling by array (3)
RNA-seq of coding RNA from single cells (2)
Unknown experiment type (1)
Human - One-color microarray (1)
Genotyping by array (1)
Comparative genomic hybridization by array (1)
Proteomic profiling by array (1)
RNA-seq of total RNA (1)
Observational (1)

Release Date

2025 (158)
2021 (152)
2022 (141)
2023 (140)
2024 (125)
2020 (118)
2019 (95)
2018 (62)
2017 (55)
2016 (46)
2015 (29)
2026 (24)
2014 (13)
2013 (3)

Lab affiliation

Baylor College of Medicine (3)
Cancer Biology Department, Fox Chase Cancer Center, Philadelphia, PA, USA (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (1)
Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, USA (1)
Cancer Signalling Research Group, School of Biomedical Science and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, AUSTRALIA. Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, AUSTRALIA. (1)
Clinical Research Division, Fred Hutchinson Cancer Research Center (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic (1)
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (1)
Department of Laboratory Medicine and Pathology, University of Minnesota (1)
Department of Medical Biotechnology and Laboratory Science College of Medicine, Chang Gung University, Taoyuan, Taiwan (1)
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States (1)
Department of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, Buffalo, New York, United States (1)
Department of Physiology & Biophysics University of California, Irvine (1)
Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000 Leuven, Belgium / Department of Obstetrics and Gynecology, University Hospitals Leuven and Department of Oncology, 3000 Leuven, Belgium / Centre for Gynecologic Oncology Amsterdam (CGOA), Antoni Van Leeuwenhoek-Netherlands Cancer Institute (AvL-NKI), University Medical Center (UMC), Amsterdam, The Netherlands (1)
Hospital for Sick Children, Toronto, Ontario, Canada (1)
INSERM U1231 Center of translational and molecular medicine Université de Bourgogne 7 Bd Jeanne d'Arc, 21000 DIJON (1)
Indiana University School of Medicine, Dept of Pediatrics; Herman B Wells Center for Pediatric Research (1)
Johns Hopkins University (1)
Kymera Therapeutics, United States (1)
Leibniz-Institut fur Analytische Wissenschaften - ISAS - e.V. (1)
Lund University (1)
Mayo Clinic (1)
Medical Biotechnology Center, VIB, Ghent, Belgium. Department of Biochemistry, Ghent University, Ghent, Belgium; (1)
Molecular Genetics, University of Toronto Hospital for Sick Children, Toronto, Canada (1)
Northwestern University (1)
Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu. Esplugues de Llobregat, 08950 Barcelona, Spain (1)
ProGenTomics Laboratory of Pharmaceutical Biotechnology, Ghent University, Belgium (1)
Professor, Human Biology, Fred Hutchinson Cancer Center, USA (1)

Location

France (1)

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Characterizing ex vivo models for studying lipid metabolism in triple negative breast cancer

Lipid metabolism drives cancer progression but is difficult to model using conventional methods. In vivo models provide circulating lipids, but are costly and low throughput, while in vitro models lack sufficient lipid availability in culture media. Here, we evaluate the chick chorioallantoic mem...

2026-07-16 | MTBLS13377 | MetaboLights

Of mice and models: Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer

- Within ovarian cancer research, patient-derived xenograft (PDX) models recapitulate histologic features and genomic aberrations found in original tumors. However, conflicting data from published studies have demonstrated significant transcriptional differences between PDXs and original tumors, whi...

ORGANISM(S): Homo sapiens (Human)

2025-04-07 | PXD054649 | Pride

RNAseq analysis of SCLC PDX models

We investigated the gene expression changes in a library of small cell lung carcinoma (SCLC) patient-derived xenograft (PDX) models.

ORGANISM(S): Homo sapiens

2022-02-07 | E-MTAB-11230 | biostudies-arrayexpress

Whole transcriptome profiling of 79 patient derived xenograft (PDX) models

RNA-Seq and a species-specific mapping strategy were used to profile the human and mouse transcriptomes of tumour samples taken from 79 PDX models representing multiple cancer types (19 x breast, 37 x lung, 8 x colorectal, 7 x ovarian, 3 x endometrial, 2 x pancreatic, 2 x ampullary, 1 x leukaemia).

ORGANISM(S): Mus musculus

2016-03-01 | E-MTAB-3980 | biostudies-arrayexpress

Genomic profiling of patient-derived xenografts identify high level â€œpassengerâ€ gene aberrations associated with better prognosis in non-small cell lung cancer

Patient-derived tumor xenografts (PDXs) increasingly are being used as preclinical models to study human cancers and to evaluate novel therapeutics, as they reflect clinical cancers more closely than established tumor cell lines. With >100 PDXs established from resected non-small cell lung carcinoma...

ORGANISM(S): Mus musculus

2016-10-26 | E-GEOD-68929 | biostudies-arrayexpress

RNA-Seq of ALDH positive and ALDH negative cells from patient-derived xenograft models of colon cancer

Colon cancer patient-derived xenograft (PDX) models were processed to single cells and sorted by FACS (BD FACS Aria II) for ALDH activity (Aldefluor assay) and DAPI. ALDH Negative and ALDH Positive cells from each PDX model were collected and lysed in RLT buffer and processed for RNA using the RNeas...

ORGANISM(S): Homo sapiens

2021-01-11 | E-MTAB-8927 | biostudies-arrayexpress

Medulloblastoma Patient-Derived Xenograft Proteomics

Proteomic and phosphoproteomic characterization of 20 orthotopic patient-derived xenograft models of medulloblastoma

ORGANISM(S): Homo sapiens (Human)

2022-09-01 | PXD035070 | Pride

Proteomics Medulloblastoma Phosphoproteomics Patient-derived xenograft (pdx) Lc-ms/ms

Expression data from 27 Asian gastric patient-derived xenograft (PDX) models

PRJNA475607 | ENA

Using a rhabdomyosarcoma patient-derived xenograft to examine precision medicine approaches and model acquired resistance.

Original patient tumor is directly implanted in mice xenografts. Tumor is propagated to multiple mice for conduct of 6 arm treatment trials and control. Therapies are selected based on T0 and F0 genomic profiles. ICE-T refractory tumor are implanted and additional 6 arm treatment trial and control c...

ORGANISM(S): Homo sapiens

2014-07-22 | E-GEOD-51130 | biostudies-arrayexpress

Establishment and characterization of testicular cancer patient-derived xenograft (PDX) models [RNA-seq]

PRJNA638873 | ENA

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