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TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
ProteomicsBioID HEK293T PAX3-FOXO1 proximity labelling
PAX3-FOXO1 is a fusion transcription factor that is the main driver of tumorigenesis leading to the development of alveolar rhabdomyosarcoma (aRMS). Since aRMS cells are addicted to PAX3-FOXO1 activity, the fusion protein also represents a major target for therapeutic interference, which is however ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-16 | PXD022187 | Pride
Bira Rhabdomyosarcoma Pax3-foxo1 Bioid 
TranscriptomicsSecreted frizzled related protein 3 (SFRP3) is required for tumorigenesis of PAX3-FOXO1-positive alveolar rhabdomyosarcoma
Alveolar rhabdomyosarcoma (aRMS) is a soft tissue sarcoma associated with the skeletal muscle lineage. The majority of aRMS tumors express the fusion protein PAX3-FOXO1 (PF), which has proven chemically intractable. As such, we identified proteins downstream from or cooperate with PF to support tu...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-67999 | biostudies-arrayexpress
GenomicsDivergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs
Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs
PRJNA750101 | ENA
ProteomicsExosomes derived from mouse myoblasts expressing PAX3-FOXO1 oncogene protect recipient cells from oxidative stress and promote plasticity
Rhabdomyosarcoma (RMS) is a highly malignant soft tissue sarcoma classified into two major histologic subtypes: embryonal (ERMS) and alveolar (ARMS). ARMS subtype is clinically more aggressive, and characterized by an oncogenic fusion protein PAX3-FOXO1 (P3F) that drives oncogenic cellular propertie...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD017543 | Pride
Exosomes Plasticity Rhabdomyosarcoma Pax3-foxo1 Oxidative stress 
GenomicsTargeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma [RNAseq_LHCN_hg19]
Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma [RNAseq_LHCN_hg19]
PRJNA830454 | ENA
GenomicsPAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma
PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma
PRJNA1210602 | ENA
GenomicsRhabdomyosarcoma transcriptomics upon PAX3-FOXO1 rescue with other fusion proteins
Rhabdomyosarcoma transcriptomics upon PAX3-FOXO1 rescue with other fusion proteins
PRJNA1052064 | ENA
GenomicsPAX3::FOXO1-Targeting PROTAC Induces Myogenic Differentiation of Fusion-Positive Rhabdomyosarcoma Cells
PAX3::FOXO1-Targeting PROTAC Induces Myogenic Differentiation of Fusion-Positive Rhabdomyosarcoma Cells
PRJNA1469021 | ENA
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
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