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GenomicsChIP-Seq for Pbx1 in the mouse E12.5 ventral midbrain
Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease One sample each for Pbx1, IgG, and input
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse long term HSC from control or Pbx1-null mice
Self-renewal is a defining characteristic of stem cells, however the molecular pathways underlying its regulation are poorly understood. Here we demonstrate that conditional inactivation of the Pbx1 proto-oncogene in the hematopoietic compartment results in a progressive loss of long-term hematopoi...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-9188 | biostudies-arrayexpress
GenomicsPrep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
Prep1 is a tumor-suppressor, whereas Meis1 is an oncogene. We show that to perform these activities in MEFs both proteins competitively hetero-dimerize with Pbx1. Meis1 alone transforms Prep1-deficient fibroblasts while Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can therefore alternati...
ORGANISM(S): Mus musculus 
2014-03-05 | E-GEOD-54221 | biostudies-arrayexpress
GenomicsPrep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis [hP]
Prep1 is a tumor-suppressor, whereas Meis1 is an oncogene. We show that to perform these activities in MEFs both proteins competitively hetero-dimerize with Pbx1. Meis1 alone transforms Prep1-deficient fibroblasts while Prep1 overexpression inhibits Meis1 tumorigenicity. Pbx1 can therefore alternati...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-58802 | biostudies-arrayexpress
ProteomicsINTEGRATED MULTI-OMICS ANALYSIS OF PBX1 IN MOUSE ADULT NEURAL STEMAND PROGENITOR CELLS IDENTIFIES A TRANSCRIPTIONAL MODULE WITH RELEVANCE TO LEUKEMOGENESIS
Developmental transcription factors act in networks, but how these networks achieve cell- and tissue specificity is still poorly understood. We here explored pre-B-cell leukemia homeobox 1 (PBX1) in adult neurogenesis combining genomic, transcriptomic, and proteomic approaches. ChIP-Seq analysis unc...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-16 | PXD048222 | Pride
Multi-omics Pbx1 Leukemogenesis 
TranscriptomicsTranscription profiling of mouse long or short term hematopoietic stem cells and the proto-oncogene Pbx1 (GEO Super Series)
This SuperSeries is composed of the following subset Series:; GSE9188: Differentially regulated genes in LT-HSC from control or Pbx1-null mice; GSE9189: Differentially regulated genes in normal LT-HSC vs ST-HSC Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-9198 | biostudies-arrayexpress
ProteomicsRIME against PBX1 protein in P19.6 mouse embryonal carcinoma cells treated for 48 hours with all-trans retinoic acid
Identification of PBX1 interactors in P19.6 mouse embryonal carcinoma cells treated for 48 hours with all-trans retinoic acid.
ORGANISM(S): Mus musculus (Mouse) 
2017-04-03 | PXD006158 | Pride
Pbx1 
TranscriptomicsTranscriptome profiling of human pre-B ALL cell line 697 upon PBX1 or TCF3 knockdown (RNA-seq)
RNA-seq was performed to observe the gene expression changes in 697 cells following shRNA-mediated knockdown of PBX Homeobox 1 (PBX1) or Transcription Factor 3 (TCF3/E2A), each with two shRNAs. Cells treated with scrambled control shRNA were used as controls.
ORGANISM(S): Homo sapiens 
2020-05-13 | E-MTAB-8179 | biostudies-arrayexpress
TranscriptomicsExpression data from control and Pbx1-null CMPs and GMPs
The capacity of the hematopoietic system to promptly respond to peripheral demands relies on adequate pools of progenitors able to transiently proliferate and differentiate in a regulated manner. However, little is known about factors that may restrain progenitor maturation to maintain their reserv...
ORGANISM(S): Mus musculus 
2013-03-31 | E-GEOD-30028 | biostudies-arrayexpress
TranscriptomicsPbx1-d Induces T cell Activation and a Decreased Apoptosis in Response to Retinoic Acids (RA)
The hypothesis was tested that the Pbx1-d isoform was responsible for the Sle1a.1 phenotypes in CD4+ T cells. Jurkat T cells were transfected with a lentiviral construct expressing Pbx1-d-GFP or control RFP. Pbx1-d over-expression reduced the percentage of late apoptotic cells in response to anti-C...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22799 | biostudies-arrayexpress
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