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ProteomicsIntegrated lipidomics and proteomics reveal cardiolipin remodelling by upregulation of HADHA and indirectly by ELOVL5 in pancreatic cancer stem cells
Pancreatic cancer stem cells (PCSCs) characterize the pancreatic ductal adenocarcinomas (PDAC) and play a key role in driving their poor outcomes and resistance to targeted therapies. Although advanced proteomics and lipidomics technology facilitates quantitation of intracellular proteins and lipids...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023069 | Pride
Pcscs Pdac Proteomics Lc-ms/ms 
TranscriptomicsGene expression of sphere-derived prostate cancer stem cells
We performed RNA-seq analysis of human prostate cancer cells and sphere-derived cancer stem cells (PCSCs) to analyze the differentially expressed genes between PCSCs and differentiated cells, and find the potential key factors in PCSCs
ORGANISM(S): Homo sapiens 
2024-03-27 | GSE228203 | GEO
TranscriptomicsCharacterization of gene profile between ALDH high LNCaP cells and ALDH low LNCaP cells
Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. Here, we show t+B13hat IMPA1-derived inositol...
ORGANISM(S): Homo sapiens 
2024-08-15 | GSE270565 | GEO
TranscriptomicsRoles of voltage-gated potassium channels in the maintenance of pancreatic cancer stem cells
The targeting of membrane proteins that are activated in cancer stem cells (CSCs) represents one of the key strategies in novel cancer therapy. The present study investigated ion channel expression profiles and functions in pancreatic CSCs (PCSCs). Cells strongly expressing aldehyde dehydrogenase 1 ...
ORGANISM(S): Homo sapiens 
2021-04-16 | GSE172185 | GEO
ProteomicsTargeting an RNA polymerase II-associated PHF5A protein subcomplex with a KMT2A-WDR5 inhibitor impairs self-renewal and tumorigenicity of pancreatic cancer stem cells
Pancreatic cancer (PC) remains one of the most aggressive and life-threatening malignancies known for its notorious resistance to chemotherapy. This is increasingly ascribed to the subpopulation of undifferentiated cells, known as pancreatic cancer stem cells (PCSCs), which are evolutionary fitter t...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD038378 | Pride
Epigenetics Cancer stem cells Pancreatic cancer Phf5a complex Kmt2a-wdr5 inhibitor 
TranscriptomicsCAMK1D activates PINK1/Parkin-dependent mitophagy to promote enzalutamide resistance in prostate cancer
Although AR-targeted therapies (e.g., enzalutamide) initially improve outcomes of prostate cancer (PCa) patients, resistance inevitably develops, driven in part by prostate cancer stem-like cells (PCSCs). However, the molecular mechanisms linking PCSCs maintenance to enzalutamide resistance (ENZR) r...
ORGANISM(S): Mus musculus 
2025-06-30 | GSE299843 | GEO
TranscriptomicsGli1⁺ Periodontal Crestal Stem Cells Orchestrate Cervical Periodontal Homeostasis and Regeneration via Cxcl12–Shh/Ihh Signaling
Reconstruction of periodontal tissue damaged by injury or disease is a long-standing clinical goal, yet its practice is hampered by a lack of mechanistic understanding of periodontal regeneration. We investigated the periodontal crestal region (POCR) in the cervical area of the mouse molar, which is...
ORGANISM(S): Mus musculus 
2026-09-08 | GSE346113 | GEO
GenomicsHNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem Cells [ChIP-seq]
The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Levels of ...
ORGANISM(S): Homo sapiens 
2018-09-04 | GSE108150 | GEO
TranscriptomicsHNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem Cells [Bru-seq]
The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Levels of ...
ORGANISM(S): Homo sapiens 
2018-09-04 | GSE108149 | GEO
UnknownRoles of voltage‑gated potassium channels in the maintenance of pancreatic cancer stem cells.
Not available
S-EPMC8425586 | biostudies-literature
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