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GenomicsDysregulated mesenchymal PDGFR-β drives kidney fibrosis
Dysregulated mesenchymal PDGFR-β drives kidney fibrosis
PRJNA577448 | ENA
TranscriptomicsConsequences of beta-PDGFR deletion on hepatic stellate cells during hepatic regeneration
Purpose: The goal of this study was to determine biological consequences during liver regeneration following partial hepatectomy in mice by next-generation sequencing. A particular interest was to compare mice with either a floxed b-PDGFR allele to mice that harbored a deletion of b-PDGFR in hepatic...
ORGANISM(S): Mus musculus 
2013-11-08 | E-GEOD-52234 | biostudies-arrayexpress
GenomicsSingle cell RNA sequencing to identify the PDGFR-β expressing lung cells
Single cell RNA sequencing to identify the PDGFR-β expressing lung cells
PRJNA765611 | ENA
TranscriptomicsDysregulated mesenchymal PDGFR-β drives kidney fibrosis
Kidney fibrosis is characterized by expansion and activation of platelet-derived growth factor receptor-β (PDGFR-β) positive mesenchymal cells. To study the consequences of PDGFR-ß activation, we developed a model of primary renal fibrosis using transgenic mice with PDGFR-β activation specifically i...
ORGANISM(S): Mus musculus 
2019-12-06 | GSE138819 | GEO
TranscriptomicsGene expression profiles of hepatic stellate cells isolated from Pdgfrb-knockout mice
Background & Aims: Rapid induction of beta-PDGF receptor (beta-PDGFR) is a core feature of hepatic stellate cell activation, the hallmark of liver fibrogenesis. However, biological consequences of the induction are not well characterized. We aimed to determine the involvement of beta-PDGFR-mediated ...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-52253 | biostudies-arrayexpress
UnknownDysregulated mesenchymal PDGFR-β drives kidney fibrosis.
Not available
S-EPMC7059015 | biostudies-literature
UnknownTargeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis.
Not available
S-EPMC4909612 | biostudies-literature
TranscriptomicsSingle cell RNA sequencing to identify the PDGFR-β expressing lung cells
Purpose:Single cell RNA sequencing to identify PDGFR-beta expressing cells in the normal adult lung Methods: Adult Pdgfrb-CreERT2, ROSA26R(Zs/+) mice were induced with tamoxifen (1mg/day for 5 days) and rested for 5 days. Lungs were then harvested and prepared to obtain single cell suspension. Live ...
ORGANISM(S): Mus musculus 
2021-09-23 | GSE184671 | GEO
ProteomicsPDGFRalpha/beta heterodimer activation negatively affects downstream ERK1/2 signaling and cellular proliferation
The platelet-derived growth factor receptor (PDGFR) family of receptor tyrosine kinases consists of two receptors, PDGFRalpha and PDGFRbeta, that homodimerize and heterodimerize upon ligand binding. Here, we tested the hypothesis that differential internalization and trafficking dynamics of the vari...
ORGANISM(S): Homo sapiens (Human) 
2025-04-25 | PXD048421 | Pride
Global proteomics Silac Pdgfr Hcc15 
UnknownRhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells.
Not available
S-EPMC4384698 | biostudies-literature
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