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TranscriptomicsTranscription profiling by array of human tumor cells with stem-like properties isolated from pediatric brain tumors
Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pe...
ORGANISM(S): Homo sapiens 
2011-09-07 | E-MEXP-2910 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain tumors and human normal brain
The characteristics of immune cells infiltrating pediatric brain tumors is largely unexplored. A better understanding of these characteristics will provide a foundation for development of immunotherapy for pediatric brain tumors. Gene expression profiles were used to identify immune marker gene that...
ORGANISM(S): Homo sapiens 
2013-08-25 | E-GEOD-50161 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of human tumor cells with stem-like properties isolated from pediatric brain tumors
Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pe...
ORGANISM(S): Homo sapiens 
2011-09-07 | E-MEXP-2909 | biostudies-arrayexpress
ProteomicsProteogenomic Discovery of Neoantigens Facilitates Personalized Multi-antigen Targeted T cell Immunotherapy for Brain Tumors
Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden and scant tissue availability. We developed a low-input proteogenomic approach combining tumor DNA/RNA sequencing and mass spectrometry proteomics to identify tumor-restricted (neoantigen) peptides arising from...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD029082 | Pride
Lc-msms Medulloblastoma Pediatric brain tumors 
TranscriptomicsMicroRNAs characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia
MicroRNAs (miRNAs) regulate activity of protein-coding genes including those involved in hematopoietic cancers. The goal of the current study was to explore which miRNAs are unique for seven different subtypes of pediatric acute lymphoblastic leukemia (ALL). Therefore, the expression levels of 397 m...
ORGANISM(S): Homo sapiens 
2011-02-11 | E-GEOD-23024 | biostudies-arrayexpress
UnknownCBTRUS Statistical Report: Pediatric Brain Tumor Foundation Childhood and Adolescent Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018.
Not available
S-EPMC9447434 | biostudies-literature
TranscriptomicsNovel Oncogenic PDGFRA Mutations in Pediatric High-Grade Gliomas
The outcome for children with high-grade gliomas (HGG) remains dismal, with a two-year survival rate of only 10-30%. Approximately half of pediatric HGGs are diffuse intrinsic pontine glioma (DIPG), a brainstem tumor that arises almost exclusively in children. Genome-wide analyses of copy number i...
ORGANISM(S): Mus musculus 
2013-11-06 | E-GEOD-46190 | biostudies-arrayexpress
ProteomicsImmune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity
Aggressive brain tumors often exhibit immunologically ‘cold’ microenvironment, where the vascular barrier impedes effective immunotherapy in poorly understood ways. Tumor vasculature also plays a pivotal role in immunoregulation and antitumor immunity. Here we show that small GTPase Rab27 controls t...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-02 | PXD062939 | Pride
Brain tumor Adoptive immunity Cytotoxic t-cells Glioma Vasculature Blood brain barrier Endothelial cells Tight junctions. Tumor microenvironment 
TranscriptomicsPediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study was to determi...
ORGANISM(S): Homo sapiens 
2013-01-21 | E-GEOD-35493 | biostudies-arrayexpress
GenomicsFunctional genomic analysis of adult and pediatric brain tumor isolates
Functional genomic analysis of adult and pediatric brain tumor isolates
PRJNA880298 | ENA
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