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MetabolomicsPoRVA G9P[23] and G5P[7] infections differentially promote PEDV replication by reprogramming glutamine metabolism
PoRVA and PEDV coinfections are extremely common in clinical practice. Although coinfections of PoRVA and PEDV are known to result in increased mortality, the underlying mechanism remains unknown. Here, we found that PoRVA infection promoted PEDV infection in vivo and in vitro and that PoRVA G9P[23]...
2024-06-10 | MTBLS9874 | MetaboLights
MetabolomicsComparative non-targeted metabolomic profiling of PEDV-infected versus uninfected neonatal piglets

Three-day-old piglets were orally inoculated with L. reuteri, with age-matched untreated piglets serving as controls. Five days post-inoculation, all piglets were challenged with PEDV. Jejunal contents were collected during acute infection for non-targeted metabolomic profiling.For non-disea...

2025-07-04 | MTBLS12632 | MetaboLights
MetabolomicsFollowing a 5-day pretreatment with Lactobacillus reuteri, HDCA, or DMSO, piglets were challenged with PEDV, and subsequent jejunal content samples were subjected to targeted bile acid metabolic profiling.

Twenty 3-day-old piglets that tested negative for both PEDV and PRRS antigens/antibodies were randomly divided into four groups: mock, DMSO, LR, and HDCA groups. The treatment groups received oral administration for five consecutive days prior to PEDV challenge. Intestinal contents were collected...

2025-07-04 | MTBLS12640 | MetaboLights
GenomicsSequence diversity of CV777 PEDV strains
Sequence diversity of CV777 PEDV strains
PRJEB20818 | ENA
ProteomicsChlorocebus sabaeus vero E6 and and eIF4E(S209A) Vero cells (S209A-Vero) LC-MSMS upon infection by coronavirus PEDV
Two rounds of TMT relative quantitative proteomics were performed to detect cellular factors involved in p-eIF4E regulation of the synthesis of viral proteins.our first round of screening identified differentially expressed proteins in PEDV-infected cells and mock-infected cells; the cellular pathwa...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2023-03-10 | PXD033916 | Pride
Chlorocebus sabaeus vero e6 Pedv And eif4e(s209a) vero cells (s209a-vero) Phosphorylation of eif4e Lc-msms 
ProteomicsDifferential membrane proteomics of PEDV infected Vero cells
PEDV wildtype strain (HNXX) infected Vero cells could form typical syncytial lesions, resulting in cell membrane rearrangement. In order to study which proteins are involved in the rearrangement of cell membrane, we infected Vero cells with PEDV. To capture the intact cell membrane at the same time ...
ORGANISM(S): Porcine Epidemic Diarrhea Virus 
2021-11-14 | PXD029763 |
TranscriptomicsCompare of differential expression profiles of PEDV-susceptible and non-susceptible cell lines at the transcriptome level to identify key molecules associated with PEDV entry
Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus that poses a serious threat to the global pig industry. Despite extensive research efforts, the functional receptor for PEDV remains unclear. In this study, we identified susceptible and non-susceptible cell lines to PEDV infection,...
ORGANISM(S): Homo sapiens 
2023-07-06 | GSE236338 | GEO
GenomicsCompare of differential expression profiles of PEDV-susceptible and non-susceptible cell lines at the transcriptome level to identify key molecules associated with PEDV entry
Compare of differential expression profiles of PEDV-susceptible and non-susceptible cell lines at the transcriptome level to identify key molecules associated with PEDV entry
PRJNA990655 | ENA
ProteomicsIdentification of cellular proteins interacting with PEDV M protein through APEX2 labeling
Membrane (M) proteins of coronaviruses are the most abundant component of the virus envelope and play crucial roles in virus assembly, virus budding and the regulation of host immunity. To understand more about these functions in the context of PEDV M protein, forty host cell proteins interacting wi...
ORGANISM(S): Sus Scrofa Scrofa 
2021-03-07 | PXD024559 |
TranscriptomicsUnraveling the battle between a highly virulent PEDV strain and the host via single-cell transcriptomic analysis
Porcine epidemic diarrhea virus (PEDV) causes severe intestinal damage and high mortality in neonatal piglets. The continuous emergence of new strains has brought new challenges to prevention and control. In this study, we isolated and characterized a prevalent PEDV virulent strain, and analyzed 19,...
ORGANISM(S): Sus scrofa 
2025-04-22 | GSE293713 | GEO
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