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TranscriptomicsTranscription profiling of human CD43+ cells isolated from myelodysplastic syndrome patients and normal controls reveals involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.
55 patients with MDS and 11 healthy controls were included in the study. At the time of investigation, 18 patients had RA, 19 RARS and 18 RAEB. The RAEB group was further subdivided into RAEB1 and RAEB2 for a selected part of the analysis. Bone marrow samples were obtained and CD34+ cells isolated f...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4619 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of bone marrow CD34+ cells from myelodysplastic syndrome patients with and without SF3B1 mutation and from healthy controls
The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ring sideroblasts (RARS). MDS is a disorder of the hematopoietic stem cell and we thus studied the transcriptome of CD34+ cells from MDS patients w...
ORGANISM(S): Homo sapiens 
2014-11-22 | E-GEOD-63569 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD34+ cells from the bone marrow of Myelodysplastic syndrome patients and healthy controls
In order to gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregu...
ORGANISM(S): Homo sapiens 
2010-03-24 | E-GEOD-19429 | biostudies-arrayexpress
TranscriptomicsMyelodysplastic Syndromes (MDS) and Acute Myeloid Leukaemia (AML)
A 10K cDNA microarray was used to compare neutrophil RNA from 21 MDS patient and 2 AML patients to pooled neutrophil RNA from 7 healthy controls.
ORGANISM(S): Homo sapiens 
2005-01-09 | E-GEOD-971 | biostudies-arrayexpress
TranscriptomicsAlpha Thalassaemia Myelodysplasia Syndrome (ATMDS)
A 10K cDNA microarray was used to compare granulocyte RNA from one ATMDS patient to pooled granulocyte RNA from 7 healthy controls.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-445 | biostudies-arrayexpress
Genomicsena-DATASET-CGP-UT-04-01-2018-02:12:18:566-617 - samples
Transcriptome sequencing was performed on 214 patients with myelodysplasia in this study. RNA was obtained from bone marrow CD34+ cells (n=100) and/or bone marrow mononuclear cells (n=165). Transcriptome sequencing was performed for both cell fractions in 51 patients. A total of 211 patients were ge...
EGAD00001003891 | EGA
GenomicsPRR14L mutations are associated with chromosome 22 acquired uniparental disomy, age related clonal hematopoiesis and myeloid neoplasia
Whole exome sequencing of 5 MDS/MPN patients to identify the target of chromosome 22 acquired uniparental disomy (22aUPD). For samples E4051 and E6523, peripheral blood leucocytes (tumour) and cultured T-cells (germline) were prepared for exome sequencing using the Agilent SureSelect kit (Agilent Te...
ORGANISM(S): Homo sapiens 
2019-01-22 | E-MTAB-7491 | biostudies-arrayexpress
GenomicsTranscriptome sequencing of myelodysplasia
Transcriptome sequencing was performed on 214 patients with myelodysplasia in this study. RNA was obtained from bone marrow CD34+ cells (n=100) and/or bone marrow mononuclear cells (n=165). Transcriptome sequencing was performed for both cell fractions in 51 patients. We also studied bone marrow CD3...
EGAS00001002346 | EGA
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