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GenomicsChromatin Signatures in Multipotent Human HSCs Indicate the Fate of Bivalent Genes during Differentiation
Histone modifications have been implicated in stem cell maintenance and differentiation. We have analyzed genome-wide changes in gene expression and histone modifications during differentiation of multipotent human primary hematopoietic stem cells/progenitor cells (HSCs/HPCs) into erythrocyte precur...
ORGANISM(S): Homo sapiens 
2009-01-09 | E-GEOD-12646 | biostudies-arrayexpress
UnknownCuI-catalyzed synthesis of multisubstituted pyrido[1,2-a]pyrimidin-4-ones through tandem Ullmann-type C-N cross-coupling and intramolecular amidation reaction.
Not available
S-EPMC10424054 | biostudies-literature
ProteomicsProteomic and metabolic profile analysis of low-temperature storage responses in Ipomoea batata Lam. tuberous roots
Our proteomic and metabolic profile analysis of sweetpotato roots stored at low temperature reveal that the antioxidant enzymes activities, proline and especially soluble sugar content were significantly increased. Most of the DEPs were implicated in phenylpropanoids and followed by starch and sucro...
ORGANISM(S): Ipomoea batatas 
2021-09-09 | PXD017728 | Pride
Proteometabolomic Chilling tolerance Low-temperature storage Sweetpotato Starch metabolism 
ProteomicsSRRM2 wt and SRRM2 S1444P interactome
Multisystem proteinopathy (MSP) is a pleiotropic degenerative disorder which affects the nervous system, muscles, and bones. The identification of risk factors and their molecular contribution to MSP expands our understanding of disease mechanisms. Here, we describe a family with dominantly inherite...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD068260 | Pride
Nuclear speckle Srrm2 Interactome 
ProteomicsIsoleucyl-tRNA synthetase interactome
Aminoacyl-tRNA synthetases are key enzymes in protein synthesis, as they catalyze the attachment of amino acids to their designated, cognate tRNAs. As such, mutations in aminoacyl-tRNA synthetases are associated with severe diseases, such as neurodevelopmental disorders. Many of these mutations fall...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD067475 | Pride
Trna Interactome 
Genomicssoil
soil Raw sequence reads
PRJNA1088976 | ENA
GenomicsFungi
Fungi Raw sequence reads
PRJNA1089105 | ENA
MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
ProteomicsTUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression
Background: The lack of obvious symptoms of early gastric cancer (GC) as well as the absence of sensitive and specific biomarkers results in poor clinical outcomes. Tubulin is currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040199 | Pride
Lncrna egfr-as1 Tuba1c Gastric cancer Cell cycle 
ProteomicsDe-2-hydroxyisobutyrylation of clusterin attenuates neuropathology and memory deficits in an Alzheimer's disease mouse model
Backgroud Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder for which there is currently no cure, representing a serious clinical challenge. Lysine 2-hydroxyisobutyrylation (Khib) is a newly discovered post-translational modification that has been found to be wid...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-04 | PXD066261 | Pride
Clusterin Adeno-associated viruse 2-hydroxyisobutyrylation Post-translational modification Alzheimer's disease 
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