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ProteomicsCharacterisation of cancer stem cells and the renin-angiotensin system in colon adenocarcinoma
LC-MS/MS Proteomics was performed to determine proteomic differences between colon adenocarcinoma (CA) tissues and patient-matched normal colon tissues, CA-derived primary cell lines and NC-derived primary cells, and between LGCA tissues and cell lines and HGCA tissues and cell lines. Biological pro...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD024449 | Pride
Crc Primary cell lines Colon adenocarcinoma Lc-ms/ms 
ProteomicsProteomics analysis of dorsal striatum reveals changes in synaptosomal proteins following ethamphetamine self-administration in rats
Methamphetamine is a widely abused, highly addictive drug. Regulation of synaptic proteins within the brain’s reward pathway modulates addiction behaviours, the progression of drug addiction and long-term changes in brain structure and function that result from drug use. Therefore, using large scale...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2015-05-06 | PXD001443 | Pride
Lc-ms/ms Rat Shotgun proteomics Synaptosome 
ProteomicsDiscovery of a cooperative mode of inhibiting RIPK1 kinase
By using Limited Proteolysis-Mass Spectrometry (LiP-MS) and Hydrogen Deuterium Exchange-Mass Spectrometry (HDX-MS) analysis, we identified the binding pocket of Nec-34 in RIPK1 kinase domain. This newly identified binding pocket of Nec-34 is distinct from distinct from that of Nec-1s.
ORGANISM(S): Homo Sapiens 
2021-03-07 | PXD024560 |
ProteomicsDiscovery of a cooperative mode of inhibiting RIPK1
We identified a peptide of RIPK1 binding with compound Nec-34
ORGANISM(S): Homo Sapiens 
2021-03-04 | PXD024534 |
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