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ProteomicsComparative glycoproteomics of embryonic stem cells identifies new players in ricin toxicity
Rapid advances in the fields of DNA-, RNA-, polypeptide-sequencing and metabolomics have markedly enhanced our understanding of fundamental biological processes. In contrast to other post-translational modifications (PTMs), the most abundant PTM, glycosylation, remains largely unexplored at the prot...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-25 | PXD005804 | Pride
Glycosylation Glycoproteomics Stem cells 
TranscriptomicsRetroviral mutagenesis in haploid ES cells
Retroviral integration sites were mapped using inverse PCR to assess preferred integration sites of this virus in the genome after infection with the retrovirus and its impact on gene expression. Inverse PCR was applied on genomic DNA to identify retroviral integration sites. Inverse PCR allows to i...
ORGANISM(S): Mus musculus 
2011-10-25 | E-GEOD-33184 | biostudies-arrayexpress
Proteomicsin vitro ubiquitination by E3 ligase Cbl-b
Fungal infections claim an estimated 1.5 million lives every year. Mechanisms that protect from fungal infections are still elusive. Recognition of fungal pathogens relies on C-type lectin receptors (CLR) and their downstream signaling kinase SYK. Here we report that the E3-ubiquitin-ligase CBL-B co...
ORGANISM(S): Homo sapiens (Human) 
2016-06-17 | PXD004256 | Pride
Lc-ms Cbl-b Ubiquitin linkage 
TranscriptomicsA role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing
Epigenetic silencing of transposons by Piwi-interacting RNAs (piRNAs) constitutes an RNA-based genome defense mechanism. Piwi endonuclease action amplifies the piRNA pool by generating new piRNAs from target transcripts by a poorly understood mechanism. Here, we identified mouse Fkbp6 as a factor in...
ORGANISM(S): Bombyx mori 
2012-09-04 | E-GEOD-39203 | biostudies-arrayexpress
TranscriptomicsThe stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Transcriptional profiling of control and MKK7-deficient primary mouse pneumocytes after oncogenic KRasG12 induction Two-condition experiment, MKK7 proficient vs. MKK7 deficient pneumocytes. 3 Biological replicates: 3 control, 3 knock out, independently grown and harvested. 3 technical replicates p...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26763 | biostudies-arrayexpress
TranscriptomicsCLP1 links tRNA metabolism to progressive motor-neuron loss
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-35924 | biostudies-arrayexpress
MetabolomicsMetabolic mapping of the human solute carrier superfamily

Solute carrier (SLC) transporters govern most of the chemical exchange across cellular membranes and are integral to metabolic regulation, which in turn is linked to cellular function and identity. Despite their key role, individual functions of the SLC superfamily members were not evaluated syst...

2025-07-22 | MTBLS11393 | MetaboLights
UnknownMetabolic mapping of the human solute carrier superfamily
Not available
S-SCDT-10_1038-S44320-025-00106-4 | biostudies-other
UnknownFIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder
Not available
S-SCDT-EMM-2022-15829 | biostudies-other
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