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ProteomicsPepSAVI-MS reveals proline-rich antimicrobial peptide in Amaranthus tricolor
PepSAVI-MS, a mass spectrometry-based peptidomics pipeline, was implemented for antimicrobial peptide (AMP) discovery in the medicinal plant Amaranthus tricolor. This investigation revealed a novel 1.7 kDa AMP, deemed Atr-AMP1. Initial efforts to determine the sequence of Atr-AMP1 utilized chemical ...
ORGANISM(S): Amaranthus tricolor 
2020-05-26 | PXD014547 | Pride
Peptidomics E. coli Mass spectrometry Amaranthus tricolor Antimicrobial peptides Pepsavi-ms Hydroxyproline 
UnknownPepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata.
Not available
S-EPMC6003877 | biostudies-literature
ProteomicsThe ‘PepSAVI-MS’ pipeline for natural product bioactive peptide discovery
The recent increase in extensively drug resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for new antibiotic backbones with novel mechanisms of action. Here, we report the development of the PepSAVI-MS pipeline for bioactive peptide d...
ORGANISM(S): Viola odorata 
2017-01-02 | PXD004780 | Pride
Anticancer Mass spectrometry Antimicrobial peptides Antifungal Antimicrobial resistance Screening platform 
UnknownExploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1.
Not available
S-EPMC6116741 | biostudies-literature
ProteomicsExploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1
Background. As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are necessary to replenish our dwindling arsenal of antimicrobial agents. To this end, we developed the PepSAVI-MS pipeline to expedite the...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2018-07-23 | PXD009003 | Pride
Peptidomics Antimicrobial peptides (amps) Bacterial secretome Mass spectrometry Enterococcus faecalis Bioactive peptides Natural products 
UnknownThe "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery.
Not available
S-EPMC8609470 | biostudies-literature
UnknownFungal Secretome Analysis via PepSAVI-MS: Identification of the Bioactive Peptide KP4 from Ustilago maydis.
Not available
S-EPMC5983367 | biostudies-literature
UnknownPepSAVI-MS Reveals a Proline-rich Antimicrobial Peptide in Amaranthus tricolor.
Not available
S-EPMC6874829 | biostudies-literature
ProteomicsBioactive natural product peptide discovery in fungal secretoms using PepSAVI-MS
Fungal secondary metabolites represent a rich and largely untapped source for bioactive molecules, including peptides with substantial structural diversity and pharmacological potential. As methods proceed to take a deep dive into fungal genomes, complimentary methods to identify bioactive component...
ORGANISM(S): Ustilago maydis virus P4 
2018-02-19 | PXD006931 | Pride
Peptidomics Mass spectrometry Fungal secretome analysis Bioactive peptides 
UnknownToo Hot to Handle: Antibacterial Peptides Identified in Ghost Pepper.
Not available
S-EPMC8600445 | biostudies-literature
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