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ProteomicsIdentification and Characterization of a Pepsin and Chymotrypsin-Resistant Peptide in the α Subunit of the 11S Globulin Legumin from Common Bean (Phaseolus vulgaris L.)
The 11S globulin legumin typically accounts for approximately 3% of total protein in common bean (Phaseolus vulgaris). It was previously reported that a legumin peptide of approximately 20 kDa is resistant to pepsin digestion. Sequence prediction suggested that the pepsin resistant peptide is locate...
ORGANISM(S): Phaseolus vulgaris (Kidney bean) (French bean) 
2024-08-09 | PXD046332 | Pride
Resistance to proteolytic digestion 11s globulin Legumin Pepsin Phaseolus vulgaris Chymotrypsin Common bean 
GenomicsAmprenavir Mitigates Pepsin-Induced Transcriptomic Changes in Normal and Precancerous Esophageal Cells
Amprenavir Mitigates Pepsin-Induced Transcriptomic Changes in Normal and Precancerous Esophageal Cells
PRJNA1218264 | ENA
TranscriptomicsGene expression profile of gliadin effects on intestinal epithelial cells suggests novel non-enzymatic functions of pepsin and trypsin
Gliadin triggers T-cell mediated immunity in celiac disease, and has cytotoxic effects on enterocytes mediated through obscure mechanisms. In addition, gliadin transport mechanisms, potential cell surface receptors and gliadin-activated downstream signaling pathways are not completely understood. In...
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-45357 | biostudies-arrayexpress
TranscriptomicsAmprenavir Mitigates Pepsin-Induced Transcriptomic Changes in Normal and Precancerous Esophageal Cells
Background: Gastroesophageal reflux disease (GERD) is a chronic condition linked to inflammatory and cancerous alterations in esophageal epithelium. Despite the widespread use of acid suppressing proton pump inhibitors (PPIs), the incidence of esophageal adenocarcinoma (EAC) keeps increasing, unders...
ORGANISM(S): Homo sapiens 
2025-02-07 | GSE288541 | GEO
ProteomicsGastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid
Protein-based targeting reagents, such as antibodies and non-antibody scaffold proteins, are rapidly inactivated in the upper gastrointestinal (GI) tract. Hydrochloric acid in gastric juice denatures proteins and activates pepsin, concentrations of which reach 1 mg/mL in the mammalian stomach. Here ...
ORGANISM(S): Escherichia coli 
2021-08-13 | PXD027071 | Pride
Sbti Protease Gastrobody 
UnknownAnalyzing pepsin degradation assay conditions used for allergenicity assessments to ensure that pepsin susceptible and pepsin resistant dietary proteins are distinguishable.
Not available
S-EPMC5312868 | biostudies-literature
UnknownLocal Synthesis of Pepsin in Barrett's Esophagus and the Role of Pepsin in Esophageal Adenocarcinoma.
Not available
S-EPMC4750403 | biostudies-literature
TranscriptomicsA Human Fetal Cochlear Cell Atlas Reveals a Regulatory Blueprint for Spatial Patterning- Stereo-seq-2
Spatial transcriptomic data was generated from human fetal cochleae of 16 post-conceptual weeks (PCW) using the Stereo-seq platform. Fresh-frozen tissues were sectioned at 10 μm thickness and mounted on pre-chilled capture chips of 0.5×0.5 cm or 1×1 cm sizes. The protocol involved on-chip tissue fix...
ORGANISM(S): Homo sapiens 
2026-02-02 | E-MTAB-16513 | biostudies-arrayexpress
UnknownPepsin homologues in bacteria.
Not available
S-EPMC2761423 | biostudies-literature
TranscriptomicsA Human Fetal Cochlear Cell Atlas Reveals a Regulatory Blueprint for Spatial Patterning- Stereo-seq
Spatial transcriptomic data was generated from human fetal cochleae across 10, 14, and 16 post-conceptual weeks (PCW) using the Stereo-seq platform. Fresh-frozen tissues were sectioned at 10 μm thickness and mounted on pre-chilled capture chips of 0.5×0.5 cm or 1×1 cm sizes. The protocol involved on...
ORGANISM(S): Homo sapiens 
2026-02-02 | E-MTAB-16462 | biostudies-arrayexpress
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