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MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
MetabolomicsPlant elicitor peptide signalling confers rice resistance to piercing-sucking insect herbivores and pathogens
Rice is a staple food crop worldwide, and its production is severely threatened by phloem-feeding insect herbivores, particularly the brown planthopper (BPH, Nilaparvata lugens), and destructive pathogens. Despite the identification of many BPH resistance genes, the molecular basis of rice resistanc...
2022-02-23 | MTBLS3518 | MetaboLights
MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
ProteomicsLocus-specific Retention Predictor (LsRP)
LsRP based on amino acid locus information and Support Vector Regression can be used to predict peptide retention time in LC-MS experiments.
ORGANISM(S): Homo sapiens (Human) 
2017-04-10 | PXD005572 | Pride
Prediction Peptide retention Lc-msms 
ProteomicsPROCAL: A set of 40 peptide standards for retention time indexing, column performance monitoring and collision energy calibration
We describe PROCAL (ProteomeTools Standard), a set of 40 synthetic peptides that span the entire hydrophobicity range of tryptic digests, enabling not only accurate determination of retention time indices but also monitoring of chromatographic separation performance over time. The fragmentation char...
ORGANISM(S): artificial sequences 
2017-09-07 | PXD006832 | Pride
Retention time kit Peptide standard Retention time calibration Proteometools Synthetic peptide 
ProteomicsConfident identification of citrullination and carbamylation assisted by peptide retention time prediction
We used 2D-LC-MS/MS methods to examine the impact of the biologically important PTM citrullination and its analogue carbamylation on peptide retention. Three first-dimension separation systems were evaluated: high-pH, HILIC and SCX, with the instrument interface separation happening at low-pH RP for...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Sus Scrofa (ncbitaxon:9823) Gallus Gallus (ncbitaxon:9031) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000086214 | MassIVE
ProteomicsRetention Order Reversal of Phosphorylated and Unphosphorylated Peptides in Reversed-Phase LC/MS
Protein phosphorylation is one of the most ubiquitous post-translational modifications in human, and trypsin-digested phosphorylated peptides have been analyzed by reversed phase LC/MS using C18-silica columns under the acidic conditions to profile human phosphoproteomes. Here, we reported that phos...
ORGANISM(S): Homo Sapiens (human) 
2018-11-11 | PXD010327 | JPOST Repository
TranscriptomicsInhibition of Staphylococcus aureus biofilm formation by gurmarin, a plant-derived cyclic peptide
Staphylococcus aureus is an opportunistic pathogen capable of causing various infections ranging from superficial skin infections to life-threatening severe diseases, including pneumonia and sepsis. This bacterium is attached to biotic and abiotic surfaces and forms biofilms that are resistant to co...
ORGANISM(S): Staphylococcus aureus 
2022-09-21 | E-MTAB-12154 | biostudies-arrayexpress
GenomicsHP1BP3, a chromatin retention factor for co-transcriptional microRNA processing (ChIP-Seq)
Identification and characterization of HP1BP3 (a human histone H1 homologue) as a novel chromatin retention factor essential for the co-transcriptional processing of pri-miRNA. We generated BAC transgenic cells at 80% confluency (~1x107) were cross-linked with 1% formaldehyde for 10 minutes at 37°C...
ORGANISM(S): Homo sapiens 
2016-07-24 | E-GEOD-77854 | biostudies-arrayexpress
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